Chronic heat stress causes liver damage via endoplasmic reticulum stress-induced apoptosis in broilers
文献类型： 外文期刊
作者： Ma, Bingbing 1 ; Xing, Tong 1 ; Li, Jiaolong 2 ; Zhang, Lin 1 ; Jiang, Yun 3 ; Gao, Feng 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Anim Sci & Technol,Joint Int Res Lab Anim Hl, Natl Expt Teaching Demonstrat Ctr Anim Sci,Key La, Jiangsu Collaborat Innovat Ctr Meat Prod & Proc Q, Nanjing 210095, Peoples R China
2.Jiangsu Acad Agr Sci, Inst Agriprod Proc, Nanjing 210014, Peoples R China
3.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China
关键词： heat stress; broiler; endoplasmic reticulum stress; liver apoptosis
期刊名称：POULTRY SCIENCE （ 影响因子：4.014； 五年影响因子：4.192 ）
ISSN： 0032-5791
年卷期： 2022 年 101 卷 10 期
页码：
收录情况： SCI
摘要： Liver is a central metabolic organ, which is sensitive to heat stress. Liver damage affects animals' health and endangers the livestock and poultry industry. This study aimed to investigate the mechanism of chronic heat stress-induced liver damage in broiler chickens. Broilers were divided into 3 treatments: normal control group (NOR, 22 degrees C), heat stress group (HS, 32 degrees C) and pair-feeding group (PF, 22 degrees C) for a 7-d and 14-d trial. The results showed that 7 d heat exposure caused microvesicular steatosis and reduced glutamine synthetase activity in broiler liver (P < 0.05). After 14 d of heat exposure, heat stress caused vacuolar degeneration and apoptosis in the liver; elevated liver relative weight and liver glutaminase activity as well as plasma ammonia level (P < 0.05). Additionally, heat stress enhanced GRP78 protein expression and the mRNA expressions of endoplasmic reticulum (ER) stress responses genes and apoptosis-related genes in broiler liver after 14 d of heat exposure (P < 0.05). In conclusion, chronic heat stress triggered ER stress-induced apoptosis and caused liver damage, which may compromise ammonia detoxification in broiler liver.
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