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Genetic characterization and phylogenetic analysis of the S genes of porcine epidemic diarrhea virus isolates from China from 2020 to 2023

文献类型： 外文期刊

作者： Wang, Yi 2 ; Qian, Jiali 1 ; Li, Yupeng 2 ; Wang, Dandan 2 ; Song, Xu 2 ; Tian, Shuo 2 ; Zhou, Jinzhu 2 ; Wang, Wei 2 ; Guo, Rongli 2 ; Li, Jizong 2 ; Zhang, Xuehan 2 ; Wang, Xianwei 1 ; Fan, Baochao 1 ; Li, Bin 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Jiangsu Key Lab Food Qual & Safety,Minist Agr,Stat, 50 Zhong Ling St, Nanjing 210014, Peoples R China

3.Hebei Agr Univ, Sch Vet Med, Baoding, Peoples R China

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

5.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

6.Jiangsu Univ, Sch Life Sci, Zhenjiang 212013, Peoples R China

7.GuoTai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 225300, Peoples R China

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.5； 五年影响因子：2.2 ）

ISSN： 0304-8608

年卷期： 2024 年 169 卷 9 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) is an enteric coronavirus that has been the main cause of diarrhea in piglets since 2010 in China. The aim of this study was to investigate sequence variation and recombination events in the spike (S) gene of PEDV isolates from China. Thirty complete S gene sequences were obtained from PEDV-positive samples collected in six provinces in China from 2020 to 2023. Phylogenetic analysis showed that 10% (3/30) belonged to subtype GII-a, 6.67% (2/30) were categorized as subtype GII-b, 66.67% (20/30) were categorized as subtype GII-c, and 16.66% (5/30) were clustered with the S-INDEL strains. Amino acid sequence alignments showed that, when compared to strains of other subtypes, the GII-c strains had two characteristic amino acid substitutions (N139D and I289M). Five S-INDEL subtype strains had a single amino acid deletion (139N) and four amino acid substitutions (N118G, T137S, A138S, and D141G). Recombination analysis allowed six putative recombination events to be identified, one involving recombination between GII-c strains, two involving GII-c and GII-b strains, two involving GII-c and GI-a strains, and one involving GII-a and GI-b strains. These results suggest that recombination between PEDV strains has been common and complex in recent years and is one of the main reasons for the continuous variation of PEDV strains.

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