The Hippo-Yki Signaling Pathway Positively Regulates Immune Response against Vibrio Infection in Shrimp
文献类型： 外文期刊
作者： Yang, Linwei 1 ; Wang, Zi-Ang 1 ; Geng, Ran 1 ; Niu, Shengwen 1 ; Zuo, Hongliang 1 ; Guo, Zhixun 5 ; Weng, Shaoping 1 ; He, Jianguo 1 ; Xu, Xiaopeng 1 ;
作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Peoples R China
2.Southern Marine Sci & Engn Guangdong Lab Zhuhai, Zhuhai 519000, Peoples R China
3.Sun Yat Sen Univ, Inst Aquat Econ Anim, Guangzhou 510275, Peoples R China
4.Sun Yat Sen Univ, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Peoples R China
5.South China Sea Fisheries Res Inst CAFS, Guangzhou 510300, Peoples R China
关键词： Penaeus vannamei; Yki; Hippo; Wts; Vibrio parahaemolyticus; signaling pathway
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）
ISSN：
年卷期： 2022 年 23 卷 19 期
页码：
收录情况： SCI
摘要： In the Hippo pathway, activation of Hippo and Warts (Wts) kinases results in the phosphorylation of Yorkie (Yki), to prevent its nuclear translocation. Shrimp aquaculture is threatened by Vibrio genus bacteria. In this study, we examine the role of the Hippo pathway in immune defense against Vibrio parahaemolyticus in Pacific white shrimp Penaeus vannamei. We show that V. parahaemolyticus infection promotes the expression of Yki and facilitates the dephosphorylation and nuclear translocation of Yki, indicating the inhibition of Hippo signaling upon bacterial infection. There is a complex regulatory relationship between the Hippo pathway components Hippo, Wts, and Yki and the immune-related transcription factors Dorsal, Relish, and STAT. Silencing of Hippo and Wts weakened hemocyte phagocytosis, while the silencing of Yki enhanced it, suggesting a positive regulation of shrimp cellular immunity by Hippo signaling activation. In vivo silencing of Hippo and Wts decreased the survival rates of V. parahaemolyticus-infected shrimp and elevated the bacterial content in tissues, while the silencing of Yki showed the opposite results. This suggests that the activation of Hippo signaling and the inhibition of Yki enhance antibacterial immunity in shrimp.
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