Lactobacillus plantarum Alters Gut Microbiota and Metabolites Composition to Improve High Starch Metabolism in Megalobrama amblycephala
文献类型： 外文期刊
作者： Qian, Linjie 1 ; Lu, Siyue 2 ; Jiang, Wenqiang 2 ; Mu, Qiaoqiao 1 ; Lin, Yan 2 ; Gu, Zhengyan 2 ; Wu, Yeyang 3 ; Ge, Xianping 1 ; Miao, Linghong 1 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Peoples R China
2.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Genet Breeding Aquat Anim & Aquaculture Bi, Wuxi 214081, Peoples R China
3.ANYOU Biotechnol Grp Co Ltd, Taicang 215421, Peoples R China
关键词： Megalobrama amblycephala; high-starch diet; Lactobacillus plantarum; metabolomics; gut microbiota
期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）
ISSN： 2076-2615
年卷期： 2025 年 15 卷 4 期
页码：
收录情况： SCI
摘要： The aim of this study was to explore the effects of adding Lactobacillus plantarum (LAB) to a high-starch diet on glucose and lipid metabolism, gut microbiota, and the composition of metabolites in Megalobrama amblycephala. This experiment was equipped with three isonitrogenous and isoenergetic feeds as control group (LW), high starch group (HW), and high starch with LAB group (HP). A total of 180 experimental fish (13.5 +/- 0.5 g) were randomly divided into three treatments, and three floating cages (1 m x 1 m x 1 m) were set up for each treatment. A total of 20 fish per net were kept in an outdoor pond for 8 weeks. The results showed that both the HW and HP groups had an altered structure and a reduced diversity of gut microbiota. LAB increased the abundance of Cetobacterium and the ratio of Firmicutes/Bacteroidota and decreased PC (16:1/20:5) and taurochenodeoxycholic acid levels. LAB promoted the expression of genes related to the intestinal bile acid cycle (fxr, hmgcr, rxr, shp and hnf4 alpha) and inhibited the expression of ppar beta and g6pase (p < 0.05). LAB reduced the expression of genes related to transported cholesterol (lxr and ldlr) (p < 0.05) in the liver. In conclusion, LAB addition could regulate the gut microbiota disorders caused by high starch levels, promote cholesterol metabolism, produce bile acids, and reduce lipid deposition.
- 相关文献
作者其他论文 更多>>
-
Effects of acute cadmium exposure on biochemistry, liver oxidative stress and transcriptomics in Songpu mirror carp (Cyprinus carpio Songpu)
作者：Fan, Ze;Wang, Yan;Li, Chenhui;Wu, Di;Wang, Liansheng;Li, Jinnan;Li, Jiaxin;Wang, Yan;Li, Jiaxin;Li, Chenhui;Miao, Linghong;Xu, Hong
关键词：Glucose abnormalities; Immune barrier; Lipid metabolism disorder; Oxidative damage; Songpu mirror carp
-
Comparative Analysis of Meat Quality and Hindgut Microbiota of Cultured and Wild Bighead Carp (Hypophthalmichthys nobilis, Richardson 1845) from the Yangtze River Area
作者：Muhammad, Abdullateef Mukhtar;Yang, Chang;Liu, Bo;Sun, Cunxin;Miao, Linghong;Zhou, Qun-Lan;Liu, Bo;Sun, Cunxin;Miao, Linghong;Zheng, Xiaochuan;Pan, Liangkun;Xia, Dong;Zhou, Qun-Lan
关键词：meat quality; e-nose; gut microbiota; bighead carp; Yangtze River
-
m6A Methylation Mediated Autophagy and Nucleotide-Binding Oligomerization Domain-like Receptors Signaling Pathway Provides New Insight into the Mitigation of Oxidative Damage by Mulberry Leaf Polysaccharides
作者：Jiang, Wenqiang;Lin, Yan;Lu, Siyue;Gu, Zhengyan;Ge, Xianping;Miao, Linghong;Jiang, Wenqiang;Qian, Linjie;Ge, Xianping;Miao, Linghong
关键词：Megalobrama amblycephala; mulberry leaf polysaccharides; m(6)A methylation; transcriptome; autophagy
-
Mulberry leaf polysaccharides ameliorate lipid metabolic disorders in high-fat diet-fed Megalobrama amblycephala: changes in intestinal transcriptome, metabolome, and microbiota
作者：Jiang, Wenqiang;Gu, Zhengyan;Lu, Siyue;Lin, Yan;Miao, Linghong;Ge, Xianping;Jiang, Wenqiang;Qian, Linjie;Mu, Qiaoqiao;Miao, Linghong;Ge, Xianping
关键词：Mulberry leaf polysaccharides; High fat metabolism; Multi-omics combined analysis
-
Application of fish protein hydrolysates in common carp (Cyprinus carpio) diets for fish meal sparing: Evidence from growth, intestinal health and microflora composition
作者：Fan, Ze;Wu, Di;Li, Chenhui;Wang, Liansheng;Li, Jinnan;Li, Chenhui;Zhang, Haitao;Zhou, Meng;Rong, Xiaohui;Miao, Linghong;Rong, Xiaohui;Zhao, Dawei;Wang, Junqing;Zhou, Meng;Wang, Liansheng
关键词：Fish protein hydrolysates (FPH); Growth; Protein synthesis; Antioxidant activity; Intestinal microflora; Common carp ( Cyprinus carpio )
-
Molecular characterization and function of hif1a and fih1 in response to acute thermal stress in American shad (Alosa sapidissima)
作者：Liang, Zhengyuan;Hu, Songqin;Miao, Linghong;Zhu, Wenbin;Wang, Lanmei;Dong, Zaije;Liang, Zhengyuan;Dong, Yalun;Miao, Linghong;Zhu, Wenbin;Fu, Jianjun;Luo, Mingkun;Wang, Lanmei;Dong, Zaije;Dong, Yalun;Miao, Linghong;Zhu, Wenbin;Fu, Jianjun;Luo, Mingkun;Wang, Lanmei;Dong, Zaije;Feng, Bingbing
关键词：Alosa sapidissima; Hypoxia-inducible factor-1 alpha; Factor inhibiting hif1 alpha; Thermal stress; Housekeeping genes selection
-
Proteomics and metabolomics analysis of American shad (Alosa sapidissima) liver responses to heat stress
作者：Luo, Mingkun;Zhu, Wenbin;Fu, Jianjun;Miao, Linghong;Dong, Zaijie;Feng, Bingbing;Xu, Wei;Liang, Zhengyuan;Dong, Zaijie
关键词：Alosa sapidissima; Liver; Heat stress; Proteome; Metabolome
