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Holothuria leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice

文献类型： 外文期刊

作者： Zhao, Fuqiang 1 ; Ma, Tingting 1 ; Zhang, Xin 1 ; Zhao, Qiancheng 2 ; Zhu, Kexue 3 ; Cao, Jun 1 ; Liu, Zhongyuan 1 ; Shen, Xuanri 1 ; Li, Chuan 1 ;

作者机构： 1.Hainan Univ, Engn Res Ctr Utilizat Trop Polysaccharide Resource, Hainan Engn Res Ctr Aquat Resources EfficientUtili, Sch Food Sci & Engn,Minist Educ, Haikou 570228, Peoples R China

2.Dalian Ocean Univ, Coll Food Sci & Engn, Dalian 116023, Peoples R China

3.Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning 571533, Peoples R China

4.Dalian Polytech Univ, Collaborat Innovat Ctr Prov & Minist Coconstructin, Dalian 116034, Peoples R China

关键词： gut microbiota; Holothuria leucospilota; immunosuppressed; metagenomics; polysaccharides

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：5.2； 五年影响因子：6.2 ）

ISSN： 1613-4125

年卷期： 2023 年 67 卷 8 期

页码：

收录情况： SCI

摘要： ScopeImmunosuppression is one of the major risk factors for a series of diseases, such as tumor, rheumatoid arthritis, and microbial infection. Various natural products have attracted wide attention due to their immunomodulatory activities. Herein, the study investigates the regulation of Holothuria leucospilota polysaccharides (HLP) in immunosuppressed mice. Methods and resultsEight-week-old female BALB/c mice are injected intraperitoneally with cyclophosphamide (80 mg kg(-1) body weight day(-1)) to establish the immunosuppressive model. After 12 days of HLP treatment, the immune organ indexes, serum cytokines, and immunoglobulin levels are significantly increased in immunosuppressed mice (p < 0.05). Real-time fluorescent quantitative polymerase chain reaction and western blotting analysis find that HLP improves the immune factors, T-cell markers, and Toll-like receptors (TLR) pathway-related proteins expression. Simultaneously, HLP significantly increases the short-chain fatty acids concentration and regulates the gut microbiota composition (p < 0.05). Furthermore, the metagenomics analysis shows that HLP increases the levels of functional genes involved in amino acid metabolism, carbohydrate metabolism, and growth activity of the gut microbiota. ConclusionHLP intervention improves the mice's immune function, and the beneficial effects are closely associated with intestinal homeostasis regulation and TLR pathway activation. This study suggests the potential for HLP as prebiotics in novel immunopotentiators development.

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