Interplay of Food-Derived Bioactive Peptides with Gut Microbiota: Implications for Health and Disease Management
文献类型： 外文期刊
作者： Hu, Mingyang 1 ; Du, Yufeng 1 ; Li, Wenyue 1 ; Zong, Xiaomei 1 ; Du, Wenjuan 1 ; Sun, Huizeng 2 ; Liu, Hongyun 2 ; Zhao, Ke 3 ; Li, Jianxiong 4 ; Farooq, Muhammad Zahid 5 ; Wu, Jianping 6 ; Xu, Qingbiao 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China
2.Zhejiang Univ, Coll Anim Sci, Inst Dairy Sci, MoE Key Lab Mol Anim Nutr, Hangzhou 310058, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310058, Peoples R China
4.Wuhan Jason Biotech Co Ltd, Wuhan 430070, Peoples R China
5.Univ Vet & Anim Sci, Dept Anim Sci, Lahore 54000, Pakistan
6.Univ Alberta, Dept Agr Food & Nutr Sci, 4-10 Ag-For Bldg, Edmonton, AB T6G 2P5, Canada
关键词： diseases; gut microbiota; immunity; oxidative stress
期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：4.5； 五年影响因子：5.6 ）
ISSN： 1613-4125
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Bioactive peptides (BPs) are protein fragments with beneficial effects on metabolism, physiology, and diseases. This review focuses on proteolytic BPs, which are produced by the action of gut microbiota on proteins in food and have demonstrated to influence the composition of gut microbes. And gut microbiota are candidate targets of BPs to alleviate oxidative stress, enhance immunity, and control diseases, including diabetes, hypertension, obesity, cancer, and immune and neurodegenerative diseases. Despite promising results, further research is needed to understand the mechanisms underlying the interactions between BPs and gut microbes, and to identify and screen more BPs for industrial applications. Overall, BPs offer potential as therapeutic agents for various diseases through their interactions with gut microbes, highlighting the importance of continued research in this area. This review focuses on bioactive peptides (BPs), which are protein fragments known for their beneficial effects on metabolism, physiology, and diseases. Specifically focusing on proteolytic BPs generated by gut microbiota from dietary proteins, these peptides have been shown to modulate gut microbial composition. They target gut microbiota to mitigate oxidative stress, boost immunity, and manage diseases such as diabetes, hypertension, obesity, cancer, and immune and neurodegenerative disorders. image
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