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New Insights into the Role and Therapeutic Potential of Heat Shock Protein 70 in Bovine Viral Diarrhea Virus Infection

文献类型： 外文期刊

作者： Chen, Nannan 1 ; Bai, Tongtong 1 ; Wang, Shuang 2 ; Wang, Huan 2 ; Wu, Yue 2 ; Liu, Yu 1 ; Zhu, Zhanbo 1 ;

作者机构： 1.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Peoples R China

2.Vet Heilongjiang Acad Agr Sci, Branch Anim Husb, Qiqihar 161006, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Bovine Dis Control Northeast China, Daqing 163319, Peoples R China

4.Engn Res Ctr Prevent & Control Cattle Dis, Daqing 163319, Peoples R China

关键词： HSP70; Flaviviridae; BVDV; antiviral; potential therapeutic target

期刊名称：MICROORGANISMS （ 影响因子：4.5； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 11 卷 6 期

页码：

收录情况： SCI

摘要： Bovine viral diarrhea virus (BVDV), a positive-strand RNA virus of the genus Pestivirus in the Flaviviridae family, is the causative agent of bovine viral diarrhea-mucosal disease (BVD-MD). BVDV's unique virion structure, genome, and replication mechanism in the Flaviviridae family render it a useful alternative model for evaluating the effectiveness of antiviral drugs used against the hepatitis C virus (HCV). As one of the most abundant and typical heat shock proteins, HSP70 plays an important role in viral infection caused by the family Flaviviridae and is considered a logical target of viral regulation in the context of immune escape. However, the mechanism of HSP70 in BVDV infection and the latest insights have not been reported in sufficient detail. In this review, we focus on the role and mechanisms of HSP70 in BVDV-infected animals/cells to further explore the possibility of targeting this protein for antiviral therapy during viral infection.

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