Response of Paenibacillus polymyxa SC2 to the stress of polymyxin B and a key ABC transporter YwjA involved
文献类型： 外文期刊
作者： Li, Hui 1 ; Wenhui, E. 1 ; Zhao, Dongying 1 ; Liu, Haiyang 1 ; Pei, Jian 1 ; Du, Binghai 1 ; Liu, Kai 1 ; Zhu, Xueming 2 ; Wang, Chengqiang 1 ;
作者机构： 1.Shandong Agr Univ, Shandong Engn Res Ctr Plant Microbia Restorat Sal, Natl Engn Res Ctr Efficient Utilizat Soil & Ferti, Coll Life Sci,Shandong Key Lab Agr Microbiol, Tai An 271018, Peoples R China
2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Treats Qual &, Hangzhou 310021, Peoples R China
关键词： Paenibacillus polymyxa; Polymyxin; Stress response; ABC transporter
期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.3； 五年影响因子：5.1 ）
ISSN： 0175-7598
年卷期： 2024 年 108 卷 1 期
页码：
收录情况： SCI
摘要： Polymyxins are cationic peptide antibiotics and regarded as the "final line of defense" against multidrug-resistant bacterial infections. Meanwhile, some polymyxin-resistant strains and the corresponding resistance mechanisms have also been reported. However, the response of the polymyxin-producing strain Paenibacillus polymyxa to polymyxin stress remains unclear. The purpose of this study was to investigate the stress response of gram-positive P. polymyxa SC2 to polymyxin B and to identify functional genes involved in the stress response process. Polymyxin B treatment upregulated the expression of genes related to basal metabolism, transcriptional regulation, transport, and flagella formation and increased intracellular ROS levels, flagellar motility, and biofilm formation in P. polymyxa SC2. Adding magnesium, calcium, and iron alleviated the stress of polymyxin B on P. polymyxa SC2, furthermore, magnesium and calcium could improve the resistance of P. polymyxa SC2 to polymyxin B by promoting biofilm formation. Meanwhile, functional identification of differentially expressed genes indicated that an ABC superfamily transporter YwjA was involved in the stress response to polymyxin B of P. polymyxa SC2. This study provides an important reference for improving the resistance of P. polymyxa to polymyxins and increasing the yield of polymyxins.
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