A comprehensive study of the colloidal properties, biocompatibility, and synergistic antioxidant actions of Antarctic krill phospholipids
文献类型： 外文期刊
作者： Su, Dong 1 ; Wang, Xixi 2 ; Liu, Xiaofang 2 ; Miao, Junkui 2 ; Zhang, Zipeng 1 ; Zhang, Yating 1 ; Zhao, Ling 1 ; Yu, Yuan 2 ; Leng, Kailiang 2 ; Yu, Yueqin 1 ;
作者机构： 1.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, State Key Lab Ecochem Engn, Qingdao 266042, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Key Lab Sustainable Dev Polar Fisheries, Minist Agr & Rural Affairs, Qingdao 266071, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266200, Peoples R China
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266071, Peoples R China
关键词： Antarctic krill; PUFAs-esterified phospholipid; Antioxidant; Synergy; Oxygen-sensitive
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2024 年 451 卷
页码：
收录情况： SCI
摘要： Excipient selection is crucial to address the oxidation and solubility challenges of bioactive substances, impacting their safety and efficacy. AKPL, a novel omega-3 polyunsaturated fatty acids (PUFAs) esterified phospholipid derived from Antarctic krill, demonstrates unique antioxidant capabilities and synergistic effects. It exhibits pronounced surface activity and electronegativity at physiological pH, as evidenced by a critical micelle concentration (CMC) of 0.15 g/L and zeta-potential of -49.9 mV. In aqueous environments, AKPL self -assembles into liposomal structures, offering high biocompatibility and promoting cell proliferation. Its polyunsaturated bond -rich structure provides additional oxidation sites, imparting antioxidant properties superior to other phospholipids like DSPC and DOPC. Additionally, AKPL augments the efficacy of lipophilic antioxidants, such as alpha-tocopherol and curcumin, in aqueous media through both intermolecular and intramolecular interactions. In sum, AKPL emerges as an innovative unsaturated phospholipid, offering new strategies for encapsulating and delivering oxygensensitive agents.
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