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First detection and complete genome analysis of porcine circovirus-like virus P1 and porcine circovirus-2 in yak in China

文献类型： 外文期刊

作者： Zhu, Jiaping 1 ; Xiao, Qi 1 ; Wen, Libin 1 ; Yin, Lihong 1 ; Zhang, Fengxi 1 ; Li, Tianjiao 2 ; Banma, Zelang 2 ; He, Kongwang 1 ; Suolang, Sizhu 2 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr & Rural Affairs, Nanjing, Peoples R China

2.Tibet Agr & Anim Husb Univ, Coll Anim Sci, Prov Key Lab Tibet Plateau Anim Epidem Dis Res, Linzhi 860000, Peoples R China

3.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

4.Minist Sci & Technol, State Key Lab Cultivat Base, Jiangsu Key Lab Food Qual & Safety, Nanjing, Peoples R China

关键词： phylogeny; porcine circovirus-like virus P1; porcine circovirus-2; sequencing; yak

期刊名称：VETERINARY MEDICINE AND SCIENCE （ 影响因子：1.772； 五年影响因子：1.885 ）

ISSN：

年卷期： 2022 年 8 卷 6 期

页码：

收录情况： SCI

摘要： Porcine circovirus-like virus P1, like porcine circovirus type 2 (PCV2), is a potential pathogen of post-weaning multisystemic wasting syndrome in swine. Yaks are a valuable species and an iconic symbol of the Tibet Plateau which is the highest and largest plateau in the world. In this study, a total of 105 yak diarrhea] samples, collected from 13 farms in Linzhi in the Tibet Plateau from January 2019 to December 2021, that were screened for P1 and PCV2 by polymerase chain reaction, 10.48% (n = 11) were positive for P1, 4.76% (n = 5) for PCV2, and 5.71% (n = 6) were positive for coinfection of P1 and PCV2. In addition, the whole genomes of eight P1 strains and eight PCV2 strains were sequenced. Alignment of deduced amino acid sequences of P1 ORF1 and PCV2 ORF2 gene revealed that ON012566 had one unique amino acid mutation at residues 137 (T to P). This mutation has important implication for the study of virus virulence, tissue tropism, and immune response. Phylogenetic analysis shows that the yak-origin P1 strains in this study with cattle-origin P1 reference strains were grouped into one cluster. The yak-origin PCV2 (ON012566) and a buffalo-origin PCV2 (KM116514) reference strain clustered in the same branch in the PCV2b regions. Meanwhile, the remaining PCV2 strains and buffalo-origin PCV2 reference strain (ON012565) clustered in the PCV2d regions. To summarize, to our knowledge, this is the first report on the molecular prevalence and genome characteristics of P1 and PCV2 in yaks in the world and will contribute to further study of the molecular epidemiology, source, and evolution of P1 and PCV2 strains.

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