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Phylogeography and evolutionary dynamics analysis of porcine delta-coronavirus with host expansion to humans

文献类型： 外文期刊

作者： Li, Gen 1 ; Zhai, Shao-Lun 2 ; Zhou, Xia 2 ; Chen, Tian-bao 1 ; Niu, Jia-wei 1 ; Xie, Yong-sheng 1 ; Si, Guang-bin 1 ; Cong, Feng 4 ; Chen, Rui-ai 1 ; He, Dong-sheng 1 ;

作者机构： 1.South China Agr Univ, Coll Vet Med, Key Lab Zoonosis Prevent & Control Guangdong Prov, 483 Wushan Rd, Guangzhou 510642, Peoples R China

2.Guangdong Acad Agr Sci, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Minist Agr Rural Affairs, Inst Anim Hlth, Guangzhou, Peoples R China

3.Key Lab Anim Dis Prevent Guangdong Prov, Guangzhou, Peoples R China

4.Guangdong Lab Anim Monitoring Inst & Guangdong, Prov Key Lab Lab Anim, Guangzhou, Peoples R China

5.Ctr Guangdong Lab Lingnan Modern Agr Sci & Techno, Zhaoqing Branch, Zhaoqing, Peoples R China

关键词： cross-species; evolution; PDCoV; phylogeography

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.521； 五年影响因子：4.529 ）

ISSN： 1865-1674

年卷期：

页码：

收录情况： SCI

摘要： From 2003 onwards, three pandemics have been caused by coronaviruses: severe acute respiratory syndrome coronavirus (SARS-CoV); middle east respiratory syndrome coronavirus (MERS-CoV); and, most recently, SARS-CoV-2. Notably, all three were transmitted from animals to humans. This would suggest that animals are potential sources of epidemics for humans. The emerging porcine delta-coronavirus was reported to infect children. This is a red flag that marks the ability of PDCoV to break barriers of cross-species transmission to humans. Therefore, we conducted molecular genetic analysis of global clade PDCoV to characterize spatiotemporal patterns of viral diffusion and genetic diversity. PDCoV was classified into three major lineages, according to distribution and phylogenetic analysis of PDCoV. It can be inferred based on the analysis results of the currently known PDCoV strains that PDCoV might originate in Asia. We also selected six special spike amino acid sequences to align and analyze to find seven significant mutation sites. The accumulation of these mutations may enhance dynamic movements, accelerating spike protein membrane fusion events and transmission. Altogether, our study offers a novel insight into the diversification, evolution, and interspecies transmission and origin of PDCoV and emphasizes the need to study the zoonotic potential of the PDCoV and comprehensive surveillance and enhanced biosecurity precautions for PDCoV.

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