Weizmannia coagulans JA845 improves atherosclerosis induced by vitamin D3 and high-fat diet in rats through modulating lipid metabolism, oxidative stress, and endothelial vascular injury
文献类型： 外文期刊
作者： Ma, Liying 1 ; Zhao, Zijian 2 ; Zhao, Yujuan 2 ; Gao, Yansong 2 ; Zhao, Lei 1 ; Li, Shengyu 2 ;
作者机构： 1.Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
2.Jilin Acad Agr Sci, Inst Agr Prod Proc Technol, Natl R&D Ctr Milk Proc, Changchun 130033, Peoples R China
3.Changchun Univ Chinese Med, Sch Pharmaceut Sci, 1035 Boshuo Rd, Changchun 130117, Jilin, Peoples R China
4.Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Sheng Tai St, Changchun 130033, Jilin, Peoples R China
关键词： Weizmannia coagulans; lipid metabolism; oxidative stress; endothelial vascular
期刊名称：JOURNAL OF APPLIED MICROBIOLOGY （ 影响因子：4.0； 五年影响因子：4.3 ）
ISSN： 1364-5072
年卷期： 2023 年 134 卷 8 期
页码：
收录情况： SCI
摘要： Aims Probiotics have been proved to be strongly linked to the occurrence and progression of atherosclerosis. This study aimed to investigate the improved effects and mechanisms underlying a potential probiotic, Weizmannia coagulans JA845, on atherosclerosis. Methods and Results Male Sprague-Dawley rats supported on a high-fat diet with vitamin D3 supplementation were subjected to W. coagulans JA845 treatment. W. coagulans JA845 obviously alleviated histological abnormalities of the abdominal aorta. After 6 weeks of W. coagulans JA845 administration, levels of TG, TC, LDL, ox-LDL, ROS, and MDA in the JA845 group decreased significantly, and those of HDL, GSH-Px, and SOD were markedly elevated. Treatment with W. coagulans JA845 also inhibited the secretion of ICAM-1 and VCAM-1 and regulated the plasma NO and eNOS content. In brief, administration of W. coagulans JA845 promoted the expression of the SIRT3/SOD2/FOXO3A pathway, inhibited the lipid metabolism pathway, SREBP-1c/FAS/DGAT2, and suppressed the JNK2/P38 MAPK/VEGF pathway implicated in endothelial injury. Conclusions These results indicated W. coagulans JA845 improved atherosclerosis by regulating lipid metabolism, antioxidative stress, and protecting against endothelial injury.
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