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Next-Generation Sequencing Reveals Four Novel Viruses Associated with Calf Diarrhea

文献类型： 外文期刊

作者： Wu, Qi 1 ; Li, Jizong 1 ; Wang, Wei 1 ; Zhou, Jinzhu 1 ; Wang, Dandan 1 ; Fan, Baochao 1 ; Zhang, Xuehan 1 ; Sun, Dongbo; 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing 210014, Peoples R China

2.Tibet Agr & Anim Husb Univ, Anim Sci Coll, Nyingchi 860000, Peoples R China

3.Minist Sci & Technol, Jiangsu Key Lab Food Qual & Safety State Key Lab, Nanjing 210014, Peoples R China

4.Jiangsu Coinfect Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China

5.Yangzhou Univ, Jiangsu Key Lab Zoonoses, Yangzhou 225009, Jiangsu, Peoples R China

6.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Lab Prevent & Control Swine Infect Dis, Daqing 163319, Peoples R China

关键词： next-generation sequencing; genome analysis; calf diarrhea; bovine kobuvirus; bovine norovirus; bovine astrovirus; bovine coronavirus

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN：

年卷期： 2021 年 13 卷 10 期

页码：

收录情况： SCI

摘要： Calf diarrhea is one of the common diseases involved in the process of calf feeding. In this study, a sample of calf diarrhea that tested positive for bovine coronavirus and bovine astrovirus was subjected to high-throughput sequencing. The reassembly revealed the complete genomes of bovine norovirus, bovine astrovirus, bovine kobuvirus, and the S gene of bovine coronavirus. Phylogenetic analysis showed that the ORF2 region of bovine astrovirus had the lowest similarity with other strains and gathered in the Mamastrovirus unclassified genogroup, suggesting a new serotype/genotype could appear. Compared with the most closely related strain, there are six amino acid mutation sites in the S gene of bovine coronavirus, most of which are located in the S1 subunit region. The bovine norovirus identified in our study was BNoV-GIII 2, based on the VP1 sequences. The bovine kobuvirus is distributed in the Aichi virus B genus; the P1 gene shows as highly variable, while the 3D gene is highly conserved. These findings enriched our knowledge of the viruses in the role of calf diarrhea, and help to develop an effective strategy for disease prevention and control.

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