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Taxifolin and Astilbin Protect Against Cadmium-Induced Oxidative Stress and Apoptosis in Chicken Liver Cells via Nrf2/HO-1 Signaling

文献类型： 外文期刊

作者： Chen, Tiezhu 1 ; Han, Tianyu 2 ; Miao, Yusong 3 ; Yan, Liangchun 1 ; Liu, Zhijun 2 ; Dong, Han 1 ; Cheng, Tingting 1 ; Liu, Yiding 2 ; Fei, Shanshan 2 ; Yang, Yu 2 ; Cheng, Guoqiang 1 ; Shi, Guangliang 2 ;

作者机构： 1.Sichuan Acad Chinese Med Sci, Chengdu 610042, Peoples R China

2.Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China

3.Heilongjiang Acad Agr Sci, Harbin 150029, Peoples R China

4.Sichuan Prov Key Lab Qual & Innovat Res Chinese Ma, Chengdu 610041, Peoples R China

5.Northeast Agr Univ, Dept Heilongjiang Common Anim Dis Prevent & Treatm, Key Lab Prov Educ, Harbin 150030, Peoples R China

6.Translat Chinese Med Key Lab Sichuan Prov, Chengdu 610041, Peoples R China

关键词： Cadmium; Astilbin; Taxifolin; Liver; Oxidative stress

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.6； 五年影响因子：3.8 ）

ISSN： 0163-4984

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Cadmium (Cd) is a toxic heavy metal pollutant widely present in the environment. It can accumulate in organisms through the food chain and pose a serious health threat to various organisms, including poultry. The liver is one of the main target organs for cadmium toxicity. This study aimed to explore the mechanism of cadmium exposure causing liver damage, and to explore the potential protective effects of Astilbin (ASB) and Taxifolin (TAX). Therefore, in vivo experiments with 60 one-day-old Hy-line brown male chickens were evenly divided into six groups: the CON, ASB, TAX, Cd + ASB, Cd + TAX, and Cd groups. On the 90th day, the Cd and metallothionein contents were detected in the chicken liver, and H&E and TEM were used to visualize pathological changes and ultrastructural damage of the liver tissue. Key indicators of oxidative stress, including the Nrf2 antioxidant system and apoptosis in chicken liver tissues, were also investigated. Tetramethylated Astilbin (TMA) was obtained by methylating the phenolic hydroxyl group of ASB and LMH cells, and was treated with ASB, TAX, TMA, and ML385 (a Nrf2 inhibitor). Results showed that ASB and TAX activated the expression of the Nrf2/HO-1 signaling pathway, promoted Nrf2 expression and nuclear translocation in chicken liver, and increased the activities of downstream antioxidant enzymes such as Glutathione (GSH), superoxide dismutase (SOD), and Total antioxidant capacity (T-AOC) by promoting Nrf2 translocation into the nucleus. It alleviated the increased expression of pro-apoptotic factors and the decreased expression of anti-apoptotic factors induced by Cd in the liver. This study shows that ASB and Tax can protect chicken livers from damage caused by early-life cadmium exposure.

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