Genomic Sequence and Transcriptome Analysis of the Medicinal Fungus Keithomyces neogunnii
文献类型： 外文期刊
作者： Long, Liangkun 1 ; Liu, Zhen 1 ; Deng, Chunying 3 ; Li, Chuanhua 4 ; Wu, Liangliang 5 ; Hou, Beiwei 5 ; Lin, Qunying 5 ;
作者机构： 1.Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilisat F, Nanjing, Peoples R China
2.Jiangsu Key Lab Chem & Utilisat Agr & Forest Biom, Nanjing, Peoples R China
3.Guizhou Acad Sci, Guizhou Inst Biol, Guiyang, Peoples R China
4.Shanghai Acad Agr Sci, Natl Engn Res Ctr Edible Fungi, Inst Edible Fungi,Shanghai Key Lab Agr Genet & Br, Key Lab Appl Mycol Resources & Utilisat,Minist Ag, Shanghai, Peoples R China
5.Nanjing Inst Comprehens Utilisat Wild Plants, Nanjing, Peoples R China
关键词： medicinal fungus; Keithomyces neogunnii; functional annotation; transcriptome analysis
期刊名称：GENOME BIOLOGY AND EVOLUTION （ 影响因子：4.065； 五年影响因子：4.216 ）
ISSN： 1759-6653
年卷期： 2022 年 14 卷 3 期
页码：
收录情况： SCI
摘要： The filamentous fungus Keithomyces neogunnii can infect the larvae of Lepidoptera (Hepialus sp.) and form an insect-fungi complex, which is utilized as an important traditional Chinese medicine. As a valuable medicinal fungus, K. neogunnii produces diverse bioactive substances (e.g., polysaccharide, vitamins, cordycepic acid, and adenosine) under cultivation conditions. Herein, we report the first high-quality genome of the K. neogunnii single-spore isolate Cg7.2a using single-molecule real-time sequencing technology in combination with Illumina sequencing. The assembled genome was 32.6 Mb in size, containing 8,641 predicted genes and having a GC content of 52.16%. RNA sequencing analysis revealed the maximum number of differentially expressed genes in the fungus during the stroma formation stage compared with those during the mycelium stage. These data are valuable to enhance our understanding of the biology, development, evolution, and physiological metabolism of K. neogunnii.
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