Hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract against carbon tetrachloride-induced hepatocyte damage in Cyprinus carpio
文献类型: 外文期刊
作者: Yin, Guojun 1 ; Cao, Liping 1 ; Xu, Pao 1 ; Jeney, Galina 2 ; Nakao, Miki 3 ;
作者机构: 1.Chinese Acad Fishery Sci, Key Open Lab Genet Breeding Aquat Animals & Aquac, Minist Agr, Freshwater Fisheries Res Ctr, Wuxi 214081, Peoples R China
2.Res Inst Fisheries Aquaculture & Irrigat, H-4440 Szarvas, Hungary
3.Kyushu Univ, Marine Biochem Lab, Grad Sch Bioresource & Bioenvironm Sci, Fukuoka 8128581, Japan
关键词: Hibiscus sabdariffa extract;Carbon tetrachloride;Hepatoprotection;Antioxidant;Cyprinus carpio
期刊名称:IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL ( 影响因子:2.416; 五年影响因子:2.117 )
ISSN: 1071-2690
年卷期: 2011 年 47 卷 1 期
页码:
收录情况: SCI
摘要: The present study aims to evaluate the hepatoprotective and antioxidant effects of Hibiscus sabdariffa extract on the carbon tetrachloride (CCl(4))-induced hepatocyte damage in fish and provide evidence as to whether it can be potentially used as a medicine for liver diseases in aquaculture. H. sabdariffa extract (100, 200, and 400 mu g/mL) was added to the carp primary hepatocyte culture before (pre-treatment), after (post-treatment), and both before and after (pre- and post-treatment) the incubation of the hepatocytes with CCl(4). CCl(4) at 8 mM in the culture medium produced significantly elevated levels of lactate dehydrogenase (LDH), glutamate oxalate transaminase (GOT), glutamate pyruvate transaminase (GPT), and malondialdehyde (MDA) and significantly reduced levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Pre-treatment and pre- and post-treatment of the hepatocytes with H. sabdariffa extract significantly reduced the elevated levels of LDH, GOT, GPT, and MDA and increased the reduced activities of SOD and GSH-Px in a dose-dependent manner; post-treatment did not show any protective effect. The results suggest that H. sabdariffa extract can be potentially used for preventing rather than curing liver diseases in fish.
- 相关文献
作者其他论文 更多>>
-
Polystyrene nanoplastics amplify the toxic effects of PFOA on the Chinese mitten crab (Eriocheir sinensis)
作者:Huang, Peng;Cao, Liping;Du, Jinliang;Guo, Yiqing;Xu, Gangchun;Gao, Jiancao;Cao, Liping;Du, Jinliang;Li, Quanjie;Sun, Yi;Zhu, Haojun;Xu, Gangchun;Gao, Jiancao
关键词:NPs; PFAS; Aquatic crustacean; Multi-omics; Combined toxicity
-
Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (Oreochromis niloticus) Through Multi-Omics Analysis
作者:Wu, Haizheng;Du, Jinliang;Cao, Liping;Xu, Gangchun;Zhu, Haojun;Li, Quanjie;Gao, Jiancao;Du, Jinliang;Cao, Liping;Sun, Yi;Xu, Gangchun
关键词:microcystin-LR; GIFT tilapia; oxidative stress; intestinal microbiota; SCFAs
-
Multi-omics and biochemical analyses provide insights into hepatic glucolipid metabolism in red tilapia ( Oreochromis spp.) under salinity stress
作者:Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Hua, Jixiang;Li, Yan;Dong, Yalun;Xu, Pao;Qiang, Jun;Huang, Renshan;Xu, Pao;Qiang, Jun
关键词:Glucolipid metabolism; Multi-omics; Physiological response; Red tilapia; Salinity stress
-
Genome-Wide Association Study and RNA-Seq Analysis Uncover Candidate Genes Controlling Growth Traits in Red Tilapia (Oreochromis spp.) Under Hyperosmotic Stress
作者:Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Xu, Pao;Qiang, Jun;Liu, Kai;Tao, Wenjing;Badran, Mohamed Fekri;Saleh, Moustafa Hassan Lotfy;Aboueleila, Rahma Halim Mahmoud;Xu, Pao;Qiang, Jun;Liu, Kai
关键词:red tilapia; growth traits; RNA-seq; GWAS; candidate gene
-
Immune response of intestinal micrornas to transport stress in hybrid yellow catfish (tachysurus fulvidraco♀ xt. vachellii♂) : response strategy and potential biomarker
作者:Zheng, Tao;Zheng, Tao;Qiang, Jun;Xu, Pao;Zheng, Tao;Tao, Yifan;Lu, Siqi;Qiang, Jun;Xu, Pao
关键词:Transport stress; Intestine; Immune regulation; Hybrid yellow catfish; RNA sequencing
-
Gut Microbe Rikenellaceae_RC9_gut_group and Knoellia-Mediated Acetic Acid Regulates Glucose and Lipid Metabolism in the Muscle of Freshwater Drum (Aplodinotus grunniens) Under High-Fat Diets
作者:Xue, Miaomiao;Xu, Pao;Wen, Haibo;Chen, Jianxiang;Kong, Changxin;Li, Xiaowei;Wang, Hang;Guo, Xinxin;Su, Yi;Li, Hongxia;Song, Changyou;Xu, Pao;Wen, Haibo;He, Jiyan;Chen, Jianxiang;Li, Hongxia;Song, Changyou
关键词:acetic acid;
Aplodinotus grunniens ; glycolipid metabolism; gut microbes; high-fat diet; muscle -
Gill and brain transcriptomic analysis of mandarin fish(Siniperca chuatsi) reveals hypoxia-induced mitochondrial dysfunction and modulation of metabolism
作者:Ding, Weidong;Cao, Liping;Cao, Zheming;Bing, Xuwen
关键词:Mandarin fish; Transcriptome; Hypoxia; DEGs



