Resveratrol Ameliorates Intestinal Damage Challenged With Deoxynivalenol Through Mitophagy in vitro and in vivo
文献类型： 外文期刊
作者： Huang, Yujian 1 ; Zheng, Changbing 1 ; Song, Bo 1 ; Wang, Li 1 ; Xiao, Hao 1 ; Jiang, Zongyong 1 ;
作者机构： 1.Guangdong Acad Agr Sci, State Key Lab Livestock & Poultry Breeding,Guangd, Minist Agr,Key Lab Anim Nutr & Feed Sci South Chi, Maoming Branch,Inst Anim Sci,Guangdong Lab Lingna, Guangzhou, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Inst Subtrop Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Peoples R China
关键词： piglets; resveratrol; deoxynivalenol; mitophagy; intestinal function
期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）
ISSN：
年卷期： 2022 年 8 卷
页码：
收录情况： SCI
摘要： Deoxynivalenol (DON) reduces growth performance and damage intestinal function, and resveratrol (RES) has positive effects on growth performance and intestinal function. The purpose of this study was to investigate the protective mechanism of RES in vitro and vivo challenged with DON. The results showed that dietary supplementation with DON significantly increase the mRNA expression levels of mitophagy- related genes, and protein level for PINK1, Parkin, Beclin-1, Lamp, Atg5, Map1lc, Bnip3, Fundc1, Bcl2l1 and SQSTMS1 (P < 0.05), while supplementation with both RES and DON decreased those indexes in the ileum. Besides DON significantly decreased protein level for Pyruvate Dehydrogenase, Cytochrome c, MFN1, OPA1, and PHB1 (P < 0.05), while supplementation with both RES and DON increased protein level for PHB1, SDHA, and VDAC in the ileum. Moreover, in vitro, we found that DON significantly decreased mitochondrial respiration (P < 0.05), while RES + DON increased the rate of spare respiratory capacity. Also, DON significantly decreased total NAD and ATP (P < 0.05), while RES + DON increased the total NAD and ATP. These results indicate that RES may ameliorates the intestinal damage challenged with deoxynivalenol through mitophagy in weaning piglets.
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