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Transcription elongator SPT6L regulates the occupancies of the SWI2/SNF2 chromatin remodelers SYD/BRM and nucleosomes at transcription start sites in Arabidopsis

文献类型： 外文期刊

作者： Shu, Jie 1 ; Ding, Ning 1 ; Liu, Jun 3 ; Cui, Yuhai 4 ; Chen, Chen 1 ;

作者机构： 1.Chinese Acad Sci, Key Lab South China Agr Plant Mol Anal & Genet Imp, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

2.Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

3.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Guangdong, Peoples R China

4.Agr & Agrifood Canada, London Res & Dev Ctr, London, ON N5V 4T3, Canada

5.Western Univ, Dept Biol, London, ON N6A 5B7, Canada

6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

期刊名称：NUCLEIC ACIDS RESEARCH （ 影响因子：19.16； 五年影响因子：17.21 ）

ISSN： 0305-1048

年卷期：

页码：

收录情况： SCI

摘要： Chromatin remodelers have been thought to be crucial in creating an accessible chromatin environment before transcription activation. However, it is still unclear how chromatin remodelers recognize and bind to the active regions. In this study, we found that chromatin remodelers SPLAYED (SYD) and BRAHMA (BRM) interact and co-occupy with Suppressor of Ty6-like (SPT6L), a core subunit of the transcription machinery, at thousands of the transcription start sites (TSS). The association of SYD and BRM to chromatin is dramatically reduced in spt6l and can be restored mainly by SPT6L Delta tSH2, which binds to TSS in a RNA polymerase II (Pol II)-independent manner. Furthermore, SPT6L and SYD/BRM are involved in regulating the nucleosome and Pol II occupancy around TSS. The presence of SPT6L is sufficient to restore the association of the chromatin remodeler SYD to chromatin and maintain normal nucleosome occupancy. Our findings suggest that the two chromatin remodelers can form protein complexes with the core subunit of the transcription machinery and regulate nucleosome occupancy in the early transcription stage.

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