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Alterations of Serum Metabolites and Fecal Microbiota Involved in Ewe Follicular Cyst

文献类型： 外文期刊

作者： Feng, Tao 1 ; Ding, Hongxiang 1 ; Wang, Jing 5 ; Xu, Wei 6 ; Liu, Yan 1 ; Kenez, Akos 6 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci BAAFS, Inst Anim Husb & Vet Med IAHVM, Beijing, Peoples R China

2.Oklahoma State Univ, Joint Lab Anim Sci IAHVM BAAFS, Beijing, Peoples R China

3.Oklahoma State Univ, Div Agr Sci & Nat Resource, Beijing, Peoples R China

4.Henan Univ Sci & Technol, Coll Anim Sci & Technol, Luoyang, Peoples R China

5.Hebei North Univ, Coll Anim Sci & Technol, Zhangjiakou, Peoples R China

6.City Univ Hong Kong, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China

关键词： sheep; follicular cysts; microbial diversity; metabolome; host-microbiota interactions

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN：

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： While the interactions of the gut microbiome and blood metabolome have been widely studied in polycystic ovary disease in women, follicular cysts of ewes have been scarcely investigated using these methods. In this study, the fecal microbiome and serum metabolome were used to compare between ewes diagnosed with ovarian cystic follicles and ewes with normal follicles, to investigate alterations of the fecal bacterial community composition and metabolic parameters in relation to follicular cystogenesis. Ewes from the same feeding and management system were diagnosed with a follicular cyst (n = 6) or confirmed to have normal follicles (n = 6) by using a B-mode ultrasound scanner. Blood serum and fresh fecal samples of all ewes were collected and analyzed. The alpha-diversity of fecal microbiome did not differ significantly between follicular cyst ewes and normal follicle ewes. Three genera (Bacteroides, Anaerosporobacter, and Angelakisella) were identified and their balance differentiated between follicular cyst and normal follicle ewes. Alterations of several serum metabolite concentrations, belonging to lipids and lipid-like molecules, organic acids and derivatives, organic oxygen compounds, benzenoids, phenylpropanoids and polyketides, and organoheterocyclic compounds, were associated with the presence of a follicular cyst. Correlation analysis between fecal bacterial communities and serum metabolites indicated a positive correlation between Anaerosporobacter and several fatty acids, and a negative correlation between Bacteroides and L-proline. These observations provide new insights for the complex interactions of the gut microbiota and the host serum lipid profiles, and support gut microbiota as a potential strategy to treat and prevent follicular cysts in sheep.

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