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Dietary rutin alleviated the damage by cold stress on inflammation reaction, tight junction protein and intestinal microbial flora in the mice intestine

文献类型： 外文期刊

作者： Guan, Peiyue 1 ; Yu, Hao 1 ; Wang, Shenao 1 ; Sun, Jing 1 ; Chai, Xuehong 1 ; Sun, Xue 1 ; Qi, Xueyan 1 ; Zhang, Ruoshi 1 ; Jiao, Yihan 1 ; Li, Zhongqiu 2 ; Kim, In Ho 3 ; Feng, Xingjun 1 ; Liu, Xiao 1 ;

作者机构： 1.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China

2.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin, Peoples R China

3.Dankook Univ, Dept Anim Resource & Sci, Anseodong, South Korea

关键词： Rutin; NF-kappa B/TLR-4 signaling pathway; Inflammation; Intestinal microbes; Intestinal histomorphology; Gut microorganisms

期刊名称：JOURNAL OF NUTRITIONAL BIOCHEMISTRY （ 影响因子：5.6； 五年影响因子：5.9 ）

ISSN： 0955-2863

年卷期： 2024 年 130 卷

页码：

收录情况： SCI

摘要： Low temperature is a common stress source for the poultry industry in the north of China. However, the low energy consuming and economical way to reduce the negative effects from cold stress is still limited. Therefore, the aim of this study was to investigate the effect of rutin on intestinal barrier in mice under low temperature. The cold stress model was established at 4 degree celsius for 3 h each day and the experiment lasted for 21 days. Forty Balb/c mice were randomly divided into four treatments: CON, normal temperature with the basal diet; RUT, normal temperature with the basal diet + 150 mg/kg body weight (BW) of rutin; CS, mice under cold stress with basal diet; CR, 150 mg/kg of BW rutin under cold stress. Rutin supplementation significantly increased the ileum villus-to-crypt ratio compared with these non-supplemented treatments. Rutin attenuated the hypothermia induced morphological damage in the ileum. In addition, rutin improved the antioxidant capacity of mice under cold stress. Rutin supplementation significantly increased the trypsin activity and inhibited the lipase in cold stressed mice. Rutin supplementation significantly inhibited the production of inflammatory factors induced by cold stress. Rutin induced the inhibition of TLR4 and NF-kappa B, thereby reducing the expression of inflammation-related genes. In addition, rutin improved the reduction of the intestinal claudin-1 and occludin expression in those mice in the cold stress (P < . 05) and improved the intestinal ZO-1 expression in cold stressed mice. Finally, rutin alleviated the dysregulation of intestinal microflora in the mice under cold stress. (c) 2024 Elsevier Inc. All rights reserved.

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