文献类型: 外文期刊
作者: Zhang, Shicui 1 ; Liang, Yujun 1 ; Ji, Guangdong 1 ; Zhuang, Zhimeng 2 ;
作者机构: 1.Ocean Univ China, Dept Marine Biol, Qingdao 266003, Peoples R China
2.Chinese Acad Fishery Sci, Yellow Sea Fishery Res Inst, Qingdao 266071, Peoples R China
关键词: Amphioxus;Branchiostoma;Immunity;Evolution
期刊名称:PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL ( 影响因子:3.607; 五年影响因子:4.795 )
ISSN: 1002-0071
年卷期: 2009 年 19 卷 8 期
页码:
收录情况: SCI
摘要: Protochordate amphioxus is an extant invertebrate regarded quite recently as a basal chordate. It has a vertebrate-like body plan including a circulation system with an organization similar to that of vertebrates. However, amphioxus is less complex than vertebrates for having a genome uncomplicated by extensive genomic duplication, and lacking lymphoid organs and free circulating blood cells. Recent studies on immunity have demonstrated the presence in amphioxus of both the constituent elements of key molecules involved in adaptive immunity such as proto-major histocompatibility complex (proto-MHC), V region-containing chitin-binding protein (VCBP) and V and C domain-bearing protein (VCP), and the complement system operating via the alternative and lectin pathways resembling those seen in vertebrates. In addition, the acute phase response profile in amphioxus has been shown to be similar to that observed in vertebrates. These findings together with the relative structural and genomic simplicity make amphioxus an ideal organism for gaining insights into the origin and evolution of the vertebrate immune system, especially adaptive immunity, and the composition and mechanisms of the vertebrate innate immunity. (C) 2009 National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Limited and Science in China Press. All rights reserved.
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