Toxic effects of Decabromodiphenyl ether (BDE-209) on thyroid of broiler chicks by transcriptome profile analysis
文献类型： 外文期刊
作者： Cheng, Lin 1 ; Yang, Junhua 1 ; Rao, Qinxiong 1 ; Liu, Zehui 1 ; Song, Wei 1 ; Guan, Shuhui 1 ; Zhao, Zhihui 1 ; Song, Weiguo 1 ;
作者机构： 1.Shanghai Acad Agr Sci, Inst Agri Food Stand & Testing Technol, Shanghai 201106, Peoples R China
关键词： Broiler chicks; Decabromodiphenyl ether; Histopathology; Thyroid hormones; Transcriptome analysis
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）
ISSN： 0147-6513
年卷期： 2021 年 219 卷
页码：
收录情况： SCI
摘要： The wide usage of decabromodiphenyl ether (BDE-209) results in its increasing occurrence in the environment and increasing attention in regard to human and animal health. BDE-209 is an endocrine disruptor for hypothyroidism, but the toxicity mechanism is unclear. Here, the histopathology and transcriptome sequencing of thyroid tissue from broiler chicks were investigated by supplemental feeding with different concentrations of BDE-209 for 42 days (0-4 g/kg in basal diet), followed by determining the levels of thyroid hormones in serum. The results showed ruptured and even hyperplastic follicular epithelial cells in the thyroid, and a total of 501 differentially expressed genes were screened out: 222 upregulated and 279 downregulated. Based on the Kyoto Encyclopedia of Genes and Genomes database, neuroactive ligand-receptor interaction pathway was significantly enriched, and alpha 1D-adrenergic receptor, follicle-stimulating hormone receptor, thyroid stimulating hormone receptor, and somatostatin receptor type 2 were shown to be candidate biomarkers. Thyroxine was a possible biomarker due to clear reduction in serum and significant correlation with exposure concentrations. These results suggested that oral intake of BDE-209 can cause structural injuries and even hyperplasia, and affect gene transcription involved in the neuroactive ligand-receptor interaction pathway of thyroid, as well as thyroid hormones in serum.
- 相关文献
作者其他论文 更多>>
-
Identification of the geographical origin of wild rice field eel (Monopterus albus) in China by stable isotopes
作者：Lv, Weiwei;Li, Muyan;Zhao, Yifan;Huang, Weiwei;Yang, Hang;Yuan, Quan;Zhang, Yuning;Zhou, Wenzong;Lu, Yangyang;Yao, Chunxia;Wang, Danhe;Song, Wei;Song, Weiguo;Li, Muyan;Zhao, Yifan;Li, Mingyou;Hu, Wei
关键词：Monopterus albus; Stable isotope; Geographical origin; Traceability; Discriminant analysis
-
Boosted antibiotic elimination over 2D/2D mesoporous CeO2/BiOCl S-scheme photocatalyst
作者：Tang, Huiling;Wang, Xuesheng;Zhang, Zhijie;Hengchao, E.;Zhou, Jiaxin;Song, Wei
关键词：S-scheme heterojunction; CeO2; BiOCl; Photocatalyst; Antibiotics
-
Combined Toxicity Assessment of Deoxynivalenol and Pb2+ on HK-2 Cells Involved in Excessive ROS-Induced Ferroptosis
作者：Zhu, Zuoyin;Wang, Jie;Cheng, Haisheng;Zhou, Xinli;Zhu, Zuoyin;Wang, Jie;Cheng, Haisheng;Zhao, Hanke;Liu, Chengbin;Yang, Junhua
关键词：ferroptosis; combined toxicity; mycotoxins; heavy metals
-
2D/2D Co3O4/BiOCl nanocomposite with enhanced antibacterial activity under full spectrum: Synergism of mesoporous structure, photothermal effect and photocatalytic reactive oxygen species
作者：Wang, Xuesheng;Zhang, Zhijie;Shao, Yi;Yao, Chunxia;Huang, Liujuan;Song, Wei;Yang, Xianli
关键词：BiOCl; Photothermal effect; Antibacterial; Photocatalysis
-
Perfluorobutane Sulfonate (PFOS) Accumulation in Tissues of Cherax quadricarinatus and Its Toxicity Mechanism
作者：Hong, Shuang;Hong, Shuang;Liu, Chengbin;Li, Yameng;Song, Wei;Wang, Xianli;Liu, Xiaoyu;Wang, Hongzhuo;Li, Kepiao;Cao, Xiaolong;Yao, Chunxia;Zhu, Tian;Lv, Weiwei
关键词：perfluoroctane sulfonate; Cherax quadricarinatus; transcriptomics; toxic effect
-
Occurrence of Co-Contamination and Interaction of Multi-Mycotoxins in Dairy Cow Feed in China
作者：Zhu, Zuoyin;Cheng, Haisheng;Wang, Jie;Zhou, Xinli;Zhu, Zuoyin;Cheng, Haisheng;Wang, Jie;Wang, Jianhua;Yang, Junhua;Ma, Junmei;Wang, Hongyang
关键词：feed; mycotoxin; co-contamination; correlation; interaction
-
Isotope Ratio Mass Spectrometry (IRMS)-Based Authentication of the Geographic Origins of Volvariella volvacea (Bull.) Singer
作者：Liu, Xing;Liu, Zhu;Li, Peijun;Liu, Xing;Rao, Qinxiong;Zhang, Qicai;Geng, Hao;Lu, Yangyang;Chen, Shanshan;Song, Weiguo;Liu, Xing;Rao, Qinxiong;Zhang, Qicai;Geng, Hao;Lu, Yangyang;Chen, Shanshan;Song, Weiguo;Liu, Zhu;Li, Peijun
关键词：
Volvariella volvacea ; stable isotope; nutrition component; geographic origin; PLS-DA
