MicroRNA miR-155 inhibits cyprinid herpesvirus 3 replication via regulating AMPK-MAVS-IFN axis
文献类型： 外文期刊
作者： Zhang, Chi 1 ; Wang, Qing 6 ; Liu, An-qi 1 ; Zhang, Chu 1 ; Liu, Lan-Hao 1 ; Lu, Long-Feng 8 ; Tu, Jiagang 1 ; Zhang, Yong-An 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan, Peoples R China
2.Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Qingdao, Peoples R China
3.Minist Educ, Engn Res Ctr Green Dev Convent Aquat Biol Ind Yang, Wuhan, Peoples R China
4.Hubei Hongshan Lab, Wuhan, Peoples R China
5.Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China
6.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Guangzhou, Peoples R China
7.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao, Peoples R China
8.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
关键词： miR-155; CyHV-3; AMPK; MAVS; Type I interferon
期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：3.605； 五年影响因子：3.833 ）
ISSN： 0145-305X
年卷期： 2022 年 129 卷
页码：
收录情况： SCI
摘要： Since emerged in the late 1990s, cyprinid herpesvirus 3 (CyHV-3) has caused huge economic losses in common and koi carp culture worldwide. Accumulating evidences suggest that teleost fish microRNA (miRNA), a class of non-coding RNA of similar to 22 nucleotides, can participate in many cellular processes, especially in host antiviral defenses. However, the roles of miRNAs in CyHV-3 infection are still unclear. Here, using high-throughput miRNA sequencing and quantitative real-time PCR (qRT-PCR) verification, we found that miR-155 was significantly upregulated in common carp brain (CCB) cells upon CyHV-3 infection. Overexpression of miR-155 effectively inhibited CyHV-3 replication in CCB cells and promoted type I interferon (IFN-I) expression. Further study revealed that miR-155 targeted the 3' untranslated region (UTR) of the mRNA of 5' AMP-activated protein kinase (AMPK), and that AMPK could interact with and degrade the mitochondrial antiviral signaling protein (MAVS), resulting in the reduction of interferon (IFN) expression. Collectively, our results show that miR155, induced by CyHV-3 infection, exhibits anti-CyHV-3 activity via regulating AMPK-MAVS-IFN axis, which will help design anti-CyHV-3 drugs.
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