文献类型： 外文期刊
作者： Xue, Mingyang 1 ; Li, Jingya 1 ; Meng, Yan 1 ; Xu, Chen 1 ; Jiang, Nan 1 ; Li, Yiqun 1 ; Fan, Yuding 1 ; Zhang, Liping 2 ; Zhou, Yong 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Hubei, Peoples R China
2.Chongqing Fisheries Tech Extens Ctr, Chongqing 401320, Peoples R China
3.Shanghai Ocean Univ, Coll Fisheries & Life Sci, Shanghai 201306, Peoples R China
关键词： Antiviral; Largemouth bass ranavirus (LMBRaV); Esculin; Largemouth bass
期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：3.8 ）
ISSN： 2352-5134
年卷期： 2024 年 34 卷
页码：
收录情况： SCI
摘要： Largemouth bass ranavirus (LMBRaV), a double-stranded DNA (dsDNA) virus, leads to considerable mortality and significant economic impacts in the largemouth bass (Micropterus salmoides) aquaculture sector. This study evaluated and screened compounds from Chinese herbs for their activity against LMBRaV. Esculin exhibited the highest rate (73 %) of inhibition on LMBRaV major capsid protein (MCP) gene expression at a concentration of 60 mg/L in a cellular environment. It also significantly reduced the cytopathic effect (CPE), protecting infected cells from LMBRaV-induced nuclear damage and hindering LMBRaV infection by modulating viral entry mechanisms. For in vivo study, esculin increased the survival rate of LMBRaV-infected largemouth bass by 60.0 % and 53.3 %, in prevention experiment and treatment experiment, respectively. Concurrently, esculin significantly reduced viral loads and induced the upregulation of antiviral-associated genes, indicating its potential for immunoregulation. In summary, esculin holds potential for both preventing and treating LMBRaV infections in the aquaculture context.
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