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Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

文献类型: 外文期刊

作者: Zhang, Yizi 1 ; Sun, Lingli 2 ; Lai, Xingfei 2 ; Peng, Xingjia 1 ; Wen, Shuai 2 ; Zhang, Zhenbiao 2 ; Xie, Yinzheng 1 ; L 1 ;

作者机构: 1.Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China

2.Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Key Lab Tea Resources Innovat & Utiliza, Guangzhou 510640, Peoples R China

3.Int Healthcare Innovat Inst Jiangmen, Jiangmen 529040, Peoples R China

关键词: Inflammation; Oxidative stress; Gastrointestinal mucosal damage; Apoptosis

期刊名称:BIOMEDICINE & PHARMACOTHERAPY ( 影响因子:6.53; 五年影响因子:5.98 )

ISSN: 0753-3322

年卷期: 2021 年 144 卷

页码:

收录情况: SCI

摘要: Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.

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