您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Insight into the current Toxoplasma gondii DNA vaccine: a review article

文献类型： 外文期刊

作者： Zhang, Xirui 1 ; Yuan, Hao 1 ; Mahmmod, Yasser S. 3 ; Yang, Zipeng 1 ; Zhao, Mengpo 1 ; Song, Yining 1 ; Luo, Shengjun 4 ; Zhang, Xiu-Xiang 5 ; Yuan, Zi-Guo 1 ;

作者机构： 1.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China

2.South China Agr Univ, Coll Vet Med, Guangdong Prov Key Lab Zoonosis Prevent & Control, Guangzhou, Peoples R China

3.Higher Coll Technol, Fac Hlth Sci, Vet Sci Div, Abu Dhabi 17155, U Arab Emirates

4.Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Peoples R China

5.South China Agr Univ, Coll Agr, Guangzhou 510642, Peoples R China

6.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China

7.South China Agr Univ, Coll Vet Med, Guangdong Prov Key Lab Zoonosis Prevent & Control, Guangzhou 510642, Guangdong, Peoples R China

关键词： Adjuvant; DNA vaccine; gene; immunization; toxoplasma gondii

期刊名称：EXPERT REVIEW OF VACCINES （ 影响因子：5.683； 五年影响因子：5.758 ）

ISSN： 1476-0584

年卷期：

页码：

收录情况： SCI

摘要： Introduction: Toxoplasma gondii (T.gondii) is a widespread protozoan with significant economic losses and public health importance. But so far, the protective effect of reported DNA-based vaccines fluctuates widely, and no study has demonstrated complete protection. Areas covered: This review provides an inclusive summary of T. gondii DNA vaccine antigens, adjuvants, and some other parameters. A total of 140 articles from 2000 to 2021 were collected from five databases. By contrasting the outcomes of acute and chronic challenges, we aimed to investigate and identify viable immunological strategies for optimum protection. Furthermore, we evaluated and discussed the impact of several parameters on challenge outcomes in the hopes of developing some recommendations to assist better future horizontal comparisons among research. Expert opinion: In the coming five years of research, the exploration of vaccine cocktails combining invasion antigens and metabolic antigens with genetic adjuvants or novel DNA delivery methods may offer us desirable protection against this multiple stage of life parasite. In addition to finding a better immune strategy, developing better in silico prediction methods, solving problems posed by variables in practical applications, and gaining a more profound knowledge of T.gondii-host molecular interaction is also crucial towards a successful vaccine.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台