Taurine alleviates oxidative stress in porcine mammary epithelial cells by stimulating the Nrf2-MAPK signaling pathway
文献类型： 外文期刊
作者： Xu, Mengmeng 1 ; Che, Long 1 ; Gao, Kaiguo 2 ; Wang, Li 2 ; Yang, Xuefen 2 ; Wen, Xiaolu 2 ; Li, Mengyun 1 ; Jiang, Zongyong 2 ;
作者机构： 1.Henan Univ Anim Husb & Econ, Coll Anim Sci & Technol, Zhengzhou, Peoples R China
2.Guangdong Acad Agr Sci, State Key Lab Livestock & poultry Breeding, Key Lab Anim Nutr & Feed Sci South China, Minist Agr,Guangdong publ Lab Anim Breeding & Nutr, Guangzhou, Peoples R China
3.Guangdong Acad Agr Sci, Inst Anim Sci, 1 Dafeng St,Wushan Rd, Guangzhou 510640, Peoples R China
关键词： Nrf2; oxidative stress; porcine mammary epithelial cells; sow
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.9； 五年影响因子：4.1 ）
ISSN： 2048-7177
年卷期： 2023 年 11 卷 4 期
页码：
收录情况： SCI
摘要： The high incidence of oxidative stress in sows during late gestation and lactation affects mammary gland health, milk yield, and milk quality. Recently, we found that supplementing maternal diets with 1% taurine improved antioxidant capability and enhanced growth performance in offspring; however, the mechanisms underlying these are unknown. This study aimed to investigate the cytoprotective effects and the mechanism of taurine in mitigating oxidative stress in porcine mammary epithelial cells (PMECs). PMECs were pretreated with 0-2.0 mM taurine for 12 h and then subjected to oxidative injury with 500 mu M hydrogen peroxide (H2O2). Pretreatment with taurine attenuated decreased cell viability, enhanced superoxide dismutase, and reduced the intracellular reactive oxygen species accumulation after H2O2 exposure. Taurine also prevented H2O2-induced endoplasmic reticulum stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) was essential to the cytoprotective effects of taurine on PMECs, as Nrf2 knockdown significantly inhibited taurine-induced cytoprotection against oxidative stress. Moreover, we confirmed that Nrf2 induction by taurine was mediated through the inactivation of the p38/MAPK pathway. Overall, taurine supplementation has beneficial effects on redox balance regulation and may protect against oxidative stress in lactating animals.
- 相关文献
作者其他论文 更多>>
-
Effect of mixed meal replacement of soybean meal on growth performance, nutrient apparent digestibility, and gut microbiota of finishing pigs
作者：He, Zhentao;Liu, Shuai;Wen, Xiaolu;Cao, Shuting;Zhan, Xianliang;Hou, Lei;Li, Yaojie;Chen, Shaozhen;Zheng, Huayu;Deng, Dongyan;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wang, Li
关键词：rapeseed meal; cotton meal; sunflower meal; finishing pigs; short-chain fatty acid
-
Effect of Miscellaneous Meals Replacing Soybean Meal in Feed on Growth Performance, Serum Biochemical Parameters, and Microbiota Composition of 25-50 kg Growing Pigs
作者：Zhan, Xianliang;Hou, Lei;He, Zhentao;Cao, Shuting;Wen, Xiaolu;Liu, Shuai;Li, Yaojie;Chen, Shaozhen;Zheng, Huayu;Deng, Dongyan;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wang, Li
关键词：miscellaneous meals; soybean meal; growth performance; microbiota
-
Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?
作者：Hong, Changming;Huang, Yujian;Cao, Shuting;Wang, Li;Yang, Xuefen;Hu, Shenglan;Gao, Kaiguo;Jiang, Zongyong;Xiao, Hao
关键词：Accurate models; Dose; Nutritional strategies; Oxidative stress; Swine
-
Maternal resveratrol improves the intestinal health and weight gain of suckling piglets during high summer temperatures: The involvement of exosome-derived microRNAs and immunoglobin in colostrum
作者：Hong, Changming;Huang, Yujian;Wen, Xiaolu;Wang, Li;Yang, Xuefen;Gao, Kaiguo;Jiang, Zongyong;Xiao, Hao;Hong, Changming;Huang, Yujian;Wen, Xiaolu;Wang, Li;Yang, Xuefen;Gao, Kaiguo;Jiang, Zongyong;Xiao, Hao;Hong, Changming;Yang, Guan
关键词：Colostrum; Exosome; Immunoglobulin; Intestinal health; Resveratrol
-
Fermented Corn-Soybean Meal Improved Growth Performance and Reduced Diarrhea Incidence by Modulating Intestinal Barrier Function and Gut Microbiota in Weaned Piglets
作者：Qiu, Yueqin;Tang, Jiaxi;Wang, Li;Yang, Xuefen;Jiang, Zongyong;Qiu, Yueqin;Tang, Jiaxi;Wang, Li;Yang, Xuefen;Jiang, Zongyong;Qiu, Yueqin;Tang, Jiaxi;Wang, Li;Yang, Xuefen;Jiang, Zongyong;Qiu, Yueqin;Tang, Jiaxi;Wang, Li;Yang, Xuefen;Jiang, Zongyong
关键词：fermented mixed feed; weaned piglets; growth performance; intestinal barrier; butyrate; gut microbiota
-
Characterization of a novel gammapartitivirus infecting the phytopathogenic fungus Pyricularia oryzae
作者：Fan, Yu;Zhao, Wenhua;Tang, Xiaolin;Wang, Li;Yang, Mei;Zhou, Erxun;He, Zhenrui;Yang, Yingqing;Cheng, Baoping
关键词：
-
Dietary supplementation with Neolamarckia cadamba leaf extract improves broiler meat quality by enhancing antioxidant capacity and regulating metabolites
作者：Wang, Cheng;Wang, Li;Wang, Cheng;Chen, Dandan;Wu, Shou;Zhou, Wei;Chen, Xiaoyang;Zhang, Qing
关键词：Neolamarckia cadamba leaf extract; Broiler; Meat quality; Antioxidant capacity; Metabolomics
