Taurine alleviates oxidative stress in porcine mammary epithelial cells by stimulating the Nrf2-MAPK signaling pathway
文献类型： 外文期刊
作者： Xu, Mengmeng 1 ; Che, Long 1 ; Gao, Kaiguo 2 ; Wang, Li 2 ; Yang, Xuefen 2 ; Wen, Xiaolu 2 ; Li, Mengyun 1 ; Jiang, Zongyong 2 ;
作者机构： 1.Henan Univ Anim Husb & Econ, Coll Anim Sci & Technol, Zhengzhou, Peoples R China
2.Guangdong Acad Agr Sci, State Key Lab Livestock & poultry Breeding, Key Lab Anim Nutr & Feed Sci South China, Minist Agr,Guangdong publ Lab Anim Breeding & Nutr, Guangzhou, Peoples R China
3.Guangdong Acad Agr Sci, Inst Anim Sci, 1 Dafeng St,Wushan Rd, Guangzhou 510640, Peoples R China
关键词： Nrf2; oxidative stress; porcine mammary epithelial cells; sow
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.9； 五年影响因子：4.1 ）
ISSN： 2048-7177
年卷期： 2023 年 11 卷 4 期
页码：
收录情况： SCI
摘要： The high incidence of oxidative stress in sows during late gestation and lactation affects mammary gland health, milk yield, and milk quality. Recently, we found that supplementing maternal diets with 1% taurine improved antioxidant capability and enhanced growth performance in offspring; however, the mechanisms underlying these are unknown. This study aimed to investigate the cytoprotective effects and the mechanism of taurine in mitigating oxidative stress in porcine mammary epithelial cells (PMECs). PMECs were pretreated with 0-2.0 mM taurine for 12 h and then subjected to oxidative injury with 500 mu M hydrogen peroxide (H2O2). Pretreatment with taurine attenuated decreased cell viability, enhanced superoxide dismutase, and reduced the intracellular reactive oxygen species accumulation after H2O2 exposure. Taurine also prevented H2O2-induced endoplasmic reticulum stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) was essential to the cytoprotective effects of taurine on PMECs, as Nrf2 knockdown significantly inhibited taurine-induced cytoprotection against oxidative stress. Moreover, we confirmed that Nrf2 induction by taurine was mediated through the inactivation of the p38/MAPK pathway. Overall, taurine supplementation has beneficial effects on redox balance regulation and may protect against oxidative stress in lactating animals.
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