文献类型： 外文期刊

作者： Wang, CY ¹ ; Duan, YR ² ; Markovic, B ² ; Barbara, J ² ; Howlett, CR ² ; Zhang, XD ² ; Zreiqat, H ² ;

作者机构： 1.Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China

2.Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China; Chinese Acad Fishery Sci, Yangtze Fisheries Inst, Jinzhou 434000, Hubei, Peoples R China; Univ New S Wales, Sch Safety Sci, Chem Safety & Toxicol Labs, Sydney, NSW 2052, Australia; Univ New S Wales, Sch Med Sci, Dept Pathol, Bone Biomat Unit, Sydney, NSW 2052, Australia

关键词： calcium phosphate ceramics;phase composition;OPG;RANKL;osteoblast

期刊名称：BIOCERAMICS, VOL 16 （ 影响因子：0.224； ）

ISSN： 1013-9826

年卷期： 2004 年 254-2 卷

页码：

收录情况： SCI

摘要： Calcium phosphate ceramics are well-known biomaterials used in orthopaedic and dental applications as bone substitute. In this study, SaOS-2 cells were grown on calcium phosphate ceramics with different phase composition for 3 and 6 days, RANKL and OPG mRNA expression were detected with quantitative in situ hybridization technique. Result showed that Saos-2 grown on tricalcium phosphate and a biphasic calcium phosphate ceramics with high tricalcium phosphate ratio expressed higher RANKL mRNA after 6 days culture. There is no significant difference in OPG expression on different surfaces after 3 days and 6 days culture. It can be concluded that tricalcium phosphate ceramics may induce more bone remodeling than hydroxyapatite when implanted in vivo.