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An edible kanamycin sulfate cross-linked cellulose active against multiple pathogenic bacteria

文献类型： 外文期刊

作者： Gu, Jun 1 ; Zhang, Shuaifeng 2 ; Xia, Xuefeng 1 ; Zhang, Xuehan 1 ; Fan, Baochao 2 ; Zhou, Junming 2 ; Zhu, Haodan 2 ; Wang, Wei 2 ; Qi, Xianghui 1 ; Li, Li 2 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China

2.Minist Agr, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Jiangsu Acad Agr Sci, Nanjing 210014, Peoples R China

3.Jiangsu Univ, Sch Mat Sci & Engn, Zhenjiang, Jiangsu, Peoples R China

4.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225000, Jiangsu, Peoples R China

5.Minist Sci & Technol, State Key Lab Cultivat Base, Jiangsu Key Lab Food Qual & Safety, Nanjing 210014, Peoples R China

关键词： Antibacterial; Carrier; Cellulose; Cross-link; Kanamycin sulfate

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）

ISSN： 0141-8130

年卷期： 2022 年 194 卷

页码：

收录情况： SCI

摘要： In this work, an edible cellulose-based antibacterial material was prepared by cross-linking alpha-cellulose and kanamycin sulfate via glutaraldehyde to form kanamycin sulfate-glutaraldehyde-cellulose. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction results indicated that the kanamycin sulfate molecule was cross-linked with the molecular chain of cellulose. The optimal mass ratio of kanamycin sulfate to alpha-cellulose was 1:100 and the degree of substitution reached 1.11%. The optimal kanamycin sulfate-glutaraldehyde-cellulose material showed an excellent inhabitation against both Gram-positive and Gram-negative bacteria. Meantime, the optimal kanamycin sulfate-glutaraldehyde-cellulose had a marked resistance to gastric acid and had low cell cytotoxicity. To promote the application of the kanamycin sulfateglutaraldehyde-cellulose material, the porous microspheres were prepared via the sol-gel method. The particle size of the homogeneous porous microspheres is mainly distributed between 1.5 and 2.0 mu m. Therefore, the kanamycin sulfate-glutaraldehyde-cellulose described herein is a potential edible, eco-friendly, potent, stable, inexpensive, and antibacterial carrier material for delivering drugs, proteins, or vaccines.

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