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Pet cats may shape the antibiotic resistome of their owner's gut and living environment

文献类型： 外文期刊

作者： Yang, Yiwen 1 ; Hu, Xinwen 2 ; Cai, Shuang 3 ; Hu, Nan 4 ; Yuan, Yilin 1 ; Wu, Yinbao 1 ; Wang, Yan 1 ; Mi, Jiandui 5 ; Liao, Xindi 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Lab Lingnan Modern Agr, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Peoples R China

2.Chinese Univ Hong Kong, Inst Digest Dis, Fac Med, Hong Kong 999077, Peoples R China

3.China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

4.Guangzhou Med Univ, Affiliated Hosp 2, Dept Rehabil, Guangzhou 510260, Peoples R China

5.Lanzhou Univ, Coll Vet Med, State Key Lab Vet Etiol Biol, Lanzhou 730000, Peoples R China

关键词： Antibiotic resistome; Pet cat; Human; Gut; Living environment

期刊名称：MICROBIOME （ 影响因子：15.5； 五年影响因子：19.4 ）

ISSN： 2049-2618

年卷期： 2023 年 11 卷 1 期

页码：

收录情况： SCI

摘要： Background Companion animals can contribute to the physical and mental health of people and often live in very close association with their owners. However, the antibiotic resistome carried by companion animals and the impact they have on their owners and living environment remain unclear. In this study, we compared the ARG profiles of cats, humans, and their living environments using metagenomic analysis to identify the core ARGs in the cat and human gut and explore the potential impact of cats on ARGs in the human gut through the environment.Results Results showed that the abundance of ARGs in the cat gut was significantly higher than that in the human gut (P < 0.0001), with aminoglycoside and tetracycline resistance genes being the dominant ARGs in the cat gut. There was no significant difference in the abundance of total ARGs in the guts of cat owners and non-owners (P > 0.05). However, the abundance of aminoglycoside resistance genes including APH(2'')-IIa and AAC(6')-Im was significantly higher in cat owners than that in non-cat owners (P < 0.001). Also, ARG abundance was positively correlated with the frequency of cat activity in the living environment. Enterobacteriaceae was the dominant ARG host co-occurring in the cat gut, human gut, and living environment.Conclusions Our results show that cats may shape the living environment resistome and thus the composition of some ARGs in the human gut, highlighting the importance of companion animal environment health.

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