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Exposure to cadmium induced gut antibiotic resistance genes (ARGs) and microbiota alternations of Babylonia areolata

文献类型： 外文期刊

作者： Zhao, Wang 1 ; Han, Qian 4 ; Yang, Rui 1 ; Wen, Weigeng 1 ; Deng, Zhenghua 1 ; Li, Huan 4 ; Zheng, Zhongming 5 ; Ma, Zhenhua 1 ; Yu, Gang 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Minist Agr & Rural Affairs, Guangzhou 510300, Peoples R China

2.Sanya Trop Fisheries Res Inst, Sanya 572018, Peoples R China

3.Key Lab Efficient Utilizat & Proc Marine Fishery R, Lingshui 572426, Peoples R China

4.Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China

5.Ningbo Univ, Sch Marine Sci, Ningbo 315823, Peoples R China

关键词： Cadmium; Antibiotic resistance genes; Intestinal microbiota; Opportunistic pathogens; Babylonia areolata

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 865 卷

页码：

收录情况： SCI

摘要： Cadmium (Cd) is widely distributed in aquatic environments and has multiple adverse effects on aquatic organisms such as the ivory shell (Babylonia areolata). However, its effects on antibiotic resistance genes (ARGs) and gut microbiota of B. areolata remain unclear. In this study, we explored the effects of different concentrations (0, 0.03, 0.18 and 1.08 mg/L) of Cd on intestinal microbial communities and ARGs in B. areolata through 16S rRNA gene sequencing and high-throughput quantitative PCR. The results showed that the structure and diversity of ARGs and microbiota in B. areolata gut were altered upon Cd exposure. Tetracycline, Vancomycin and Macrolide-Lincosamide-Streptogramin B (MLSB) resistance genes were identified as the major ARGs in B. areolata gut. The absolute abundance and alpha diversity of ARGs in B. areolata gut increased with the rise of cadmium concentration. The microbial communities at genus level were enriched in the low and medium Cd concentration groups, while decreased in the high Cd concentration group compared to the control groups. In addition, the influence of microbiota on the ARG profile was more significant than that of Cd concen-tration and MGEs in B. areolata gut. Null model analysis demonstrated that stochastic processes dominated ARG assembly in the Cd-exposed groups and were enhanced with the increasing Cd concentrations. Four opportunistic bacterial pathogens (Bacteroides, Legionella, Acinetobacter and Escherichia) detected in B. areolata gut maybe the potential hosts of ARGs. Our findings provide references for the hazards assessment of environmental Cd exposure of gut microbiome in aquatic animals.

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