Genomic Structure and Molecular Characterization of Toll-like Receptors in Black Scraper Thamnaconus Modestus and Their Expression Response to Two Types of Pathogens
文献类型： 外文期刊
作者： Han, Fei 1 ; Zhang, Yuan 2 ; Xu, Anle 3 ; Song, Na 1 ; Qin, Geng 2 ; Wang, Xiaoyan 3 ; Chen, Siqing 4 ; Bian, Li 4 ; Gao, Tianxiang 3 ;
作者机构： 1.Ocean Univ China, Fishery Coll, Qingdao 266003, Shandong, Peoples R China
2.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China
3.Zhejiang Ocean Univ, Fisheries Coll, Zhoushan 316022, Zhejiang, Peoples R China
4.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao 266003, Shandong, Peoples R China
关键词： Thamnaconus modestus; Toll-like receptors; Lipopolysaccharide; Poly (I; C); Genome
期刊名称：MARINE BIOTECHNOLOGY （ 影响因子：3.0； 五年影响因子：3.4 ）
ISSN： 1436-2228
年卷期： 2023 年
页码：
收录情况： SCI
摘要： The black scraper (Thamnaconus modestus) is an important commercial species in China. However, with the rapid expansion of aquaculture, the culture of this species faces substantial economic losses due to infectious diseases. Toll-like receptors (TLRs) recognize a wide range of pathogen-associated molecular patterns (PAMPs) and play a crucial role in disease resistance by initiating innate immune responses in the host. The genome of the black scraper comprises eight TLR members, which can be classified into five subfamilies based on evolutionary analysis. Moreover, the TmTLRs were identified on 6 out of the 20 chromosomes in the black scraper. The functional similarity within the same subfamilies is evident by conserved motifs and gene structures. The qRT-PCR experiments revealed diverse TmTLR expression patterns in the liver, intestine, spleen, head kidney, heart, and brain of black scrapers, with high expression levels observed in immune organs, suggesting that TmTLRs may participate in the regulation of immune mechanisms and other physiological functions in the black scraper. At least six TmTLRs showed significantly upregulated expression in response to poly (I: C) or lipopolysaccharide (LPS) stresses, thus indicating their potential roles in regulating abiotic stress responses. In conclusion, our findings not only provide a foundation for future research on the TLR gene family in the black scraper but also offer guidance for disease prevention and vaccine development.
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