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Exopolysaccharide from Lactobacillus rhamnosus ZFM231 alleviates DSS-induced colitis in mice by regulating gut microbiota

文献类型： 外文期刊

作者： Wan, Cheng 1 ; Qian, Wen-Wen 1 ; Liu, Wei 2 ; Pi, Xionge 2 ; Tang, Meng-Ting 1 ; Wang, Xiao-Lin 3 ; Gu, Qing 1 ; Li, Ping 1 ; Zhou, Tao 1 ;

作者机构： 1.Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Hangzhou 310018, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Zhejiang, Peoples R China

3.Zhejiang Pharmaceut Coll, Faulty Food Sci, Ningbo, Zhejiang, Peoples R China

关键词： Lactobacillus rhamnosus; exopolysaccharide; gut microbiota; DSS-induced colitis; short-chain fatty acid

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.125； 五年影响因子：4.096 ）

ISSN： 0022-5142

年卷期：

页码：

收录情况： SCI

摘要： BACKGROUND The exopolysaccharides (EPS) produced by Lactobacillus and other probiotics are associated with many benefits, such as immune regulation, antioxidant properties, antitumor effect, and regulation of intestinal microbe homeostasis. In the present study, the modulatory effect of EPS produced by Lactobacillus rhamnosus ZFM231 on the intestinal flora of mice with inflammatory bowel disease induced by dextran sulfate solution was investigated. RESULTS Results indicated that weight loss, colonic length, the disease activity index score and colonic tissue damage in mice were significantly improved by EPS treatment. Compared with the model group, in the EPS-treated group, the diversity of and the composition of gut microbiota at both phylum and genus levels were found to recover to the levels of normal group, indicating the effective modulation on gut microbiota by EPS; short-chain fatty acids, including acetic acid, propionic acid and butyric acid produced by intestinal microbial metabolism, increased significantly; the level of anti-inflammatory factor transforning growth factor-beta significantly increased and the level of pro-inflammatory factor tumor necrosis factor-alpha significantly decreased in the colonic cells of EPS-treated mice. CONCLUSION It is clear that EPS produced by L. rhamnosus ZFM231 could find application in functional foods with the property of anti-ulcerative colitis. The experimental results provide new insights into the probiotic effect of EPS. (c) 2022 Society of Chemical Industry.

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