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A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study

文献类型： 外文期刊

作者： Yang, Bo 1 ; Wang, Fuhao 1 ; Hu, Huiyu 1 ; Li, Ruonan 1 ; Lv, Xiaoling 3 ; Sun, Xueyan 1 ; Zhou, Danna 2 ; Yu, Daojin 1 ;

作者机构： 1.Fujian Agr & Forestry Univ, Univ Key Lab Integrated Chinese Tradit & Western V, Fujian Key Lab Tradit Chinese Vet Med & Anim Hlth, Fuzhou 350002, Peoples R China

2.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Key Lab Prevent & Control Agents Anim Bacteriosis, Hubei Prov Key Lab Anim Pathogen Microbiol,Minist, Wuhan 430064, Peoples R China

3.Fujian Sunner Dev Co Ltd, Nanping 354100, Peoples R China

关键词： Matrine; Non-extractable residue; Edible porcine tissue; Enzymolysis; Liquid chromatography-tandem mass spectrometry

期刊名称：MICROCHEMICAL JOURNAL （ 影响因子：5.1； 五年影响因子：4.7 ）

ISSN： 0026-265X

年卷期： 2024 年 207 卷

页码：

收录情况： SCI

摘要： Matrine (MT), a phytochemical with various anti-infective activities, is expected to become a therapeutic agent against bacterial, viral, and parasitic infections in pigs. However, food safety risks associated with MT have not yet been evaluated. In the present study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to determine total MT residues in edible porcine tissues. The tissue samples were hydrolyzed with trypsin to release non-extractable MT. The hydrolysates were extracted with a trichloroacetic acid solution. Tissue extracts were purified using solid-phase extraction and subjected to LC-MS/MS. The method was fully validated according to the United States Food and Drug Administration (USFDA) guidelines and applied to investigate the tissue residue depletion of MT in pigs. Significant accumulation of MT was observed in edible porcine tissues. Notably, MT showed no persistent tissue residue in this study and could be accepted as a safe anti-infective agent in pigs.

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