Effects of myonectin on porcine intramuscular adipocyte differentiation and exogenous free fatty acid utilization
文献类型： 外文期刊
作者： Sun, Zhuwen 1 ; Liu, Zhengqun 1 ; Xi, Jingning 2 ; Liu, Yanrong 1 ; Zheng, Zi 1 ; Li, Ning 1 ; Li, Zeqing 4 ; Liang, Shiyue 1 ; Li, Qianjun 1 ; Zhang, Hongfu 3 ; Yan, Jun 1 ; Sun, Chao 2 ; Mu, Shuqin 1 ;
作者机构： 1.Tianjin Acad Agr Sci, Inst Anim Sci & Vet, Tianjin Engn Res Ctr Anim Hlth Farming, Tianjin Key Lab Anim Mol Breeding & Biotechnol, Tianjin, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Peoples R China
3.Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
4.Tianjin Agr Dev Serv Cent, Tianjin, Peoples R China
关键词： Myonectin; porcine intramuscular adipocytes; free fatty acid; lipid deposition
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：3.7； 五年影响因子：3.3 ）
ISSN： 1049-5398
年卷期： 2023 年
页码：
收录情况： SCI
摘要： As an important factor secreted by skeletal muscle, myonectin can regulate lipid metabolism and energy metabolism, but its role in the utilization of peripheral free fatty acids (FFAs) by porcine intramuscular fat cells remains to be further investigated. In this study, porcine intramuscular adipocytes were treated with recombinant myonectin and palmitic acid (PA), either alone or in combination, and then were examined for their uptake of exogenous FFAs, intracellular lipid synthesis and catabolism, and mitochondrial oxidation of fatty acids. The results showed that myonectin decreased the area of lipid droplets in intramuscular adipocytes (p < 0.05) and significantly increased (p < 0.05) the expression levels of hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL). Moreover, myonectin can up-regulate the expression of p38 mitogen-activated protein kinase (p38 MAPK). Myonectin significantly promoted the uptake of peripheral FFAs (p < 0.01), improved (p < 0.05) the expression of fatty transport protein 1 (FATP1) and fatty acid binding protein 4 (FABP4) in intramuscular adipocytes. Myonectin also significantly increased (p < 0.05) the expression levels of fatty acid oxidation markers: transcription factor (TFAM), uncoupling protein-2 (UCP2) and oxidative respiratory chain marker protein complex I (NADH-CoQ) in mitochondria of intramuscular adipocytes. In summary, myonectin promoted the absorption, transport, and oxidative metabolism of exogenous FFAs in mitochondria, thereby inhibiting lipid deposition in porcine intramuscular adipocytes.
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