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pitp beta_w Encoding Phosphatidylinositol Transfer Protein Is Involved in Female Differentiation of Chinese Tongue Sole, Cynoglossus semilaevis

文献类型： 外文期刊

作者： Sun, Yuxuan 1 ; Zhang, Mengqian 1 ; Cheng, Peng 1 ; Gong, Zhihong 1 ; Li, Xihong 1 ; Wang, Na 1 ; Wei, Min 2 ; Xu, Xiaodong 3 ; Xu, Wenteng 1 ;

作者机构： 1.Chinese Acad Fishery Sci CAFS, Yellow Sea Fisheries Res Inst, Lab Marine Fisheries Sci & Food Prod Proc, Pilot Natl Lab Marine Sci & Technol, Qingdao, Peoples R China

2.Jiangsu Ocean Univ, Lianyungang, Peoples R China

3.Qingdao Vland Biotech Co Grp, Qingdao, Peoples R China

关键词： Cynoglossus semilaevis; pitp beta_w; female differentiation; oogenesis; RNA interference

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.772； 五年影响因子：4.933 ）

ISSN：

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： Phosphatidylinositol transfer protein (pitp) plays an important role in phospholipid transfer in animals. A pitp variant (pitp beta_w) in Chinese tongue sole was identified by transcriptomic analysis for its female-biased expression. The coding sequence of pitp beta_w was 816 bp, encoding a 371-amino-acid protein. pitp beta_w showed female-biased expression and was relatively high in brain, muscle, and ovary tissues. In different developmental stages of the ovary, pitp beta_w could be detected from 40 days until 3 years post hatching, and the highest expression was observed at 90 days. In situ hybridization revealed that pitp beta_w was predominantly localized in early-stage oocytes (I-III stages). After siRNA-mediated knockdown of pitp beta_w in an ovarian cell line, the expression of sox9a was reduced, while that of figla_tv1 and sox9b was significantly increased. Our findings suggest that pitp beta_w might be involved in female differentiation and early oogenesis.

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