Mulberry leaf extract improves intestinal barrier function and displays beneficial effects on colonic microbiota and microbial metabolism in weaned piglets
文献类型： 外文期刊
作者： Song, Min 1 ; Wang, Chaopu 1 ; Yu, Miao 1 ; Deng, Dun 1 ; Liu, Zhichang 1 ; Cui, Yiyang 1 ; Tian, Zhimei 1 ; Rong, Ting 1 ; Li, Zhenming 1 ; Ma, Xianyong 1 ; Ti, Junling 3 ;
作者机构： 1.Guangdong Acad Agr Sci, Inst Anim Sci, State Key Lab Livestock & Poultry Breeding,Guangd, Key Lab Anim Nutr & Feed Sci South China,Minist A, Guangzhou 510640, Peoples R China
2.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Maoming, Peoples R China
3.Guangdong Guanghui Agr & Anim Husb Co Ltd, Shaoguan, Peoples R China
关键词： weaned piglets; mulberry leaf extract; intestinal barrier function; colon microbes; microbial metabolites
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.125； 五年影响因子：4.096 ）
ISSN： 0022-5142
年卷期：
页码：
收录情况： SCI
摘要： BACKGROUND Mulberry leaf extract (MLE) extracted from mulberry leaves is rich in a variety of bioactive ingredients and can be used as feed additives of weaned piglets. The present study was conducted to evaluate the effects of dietary MLE supplementation on intestinal barrier function, colon microbial numbers and microbial metabolites of weaned piglets. RESULTS MLE supplementation increased the villus height and the villus height/crypt depth ratio in jejunum and ileum (P < 0.05), increased the mRNA expression of ZO-1, Claudin-1 and MUC-2 in the ileal mucosa (P < 0.05), and decreased the serum level of lipopolysaccharide (P < 0.01). Meanwhile, MLE reduced the mRNA expression of tumor necrosis factor-alpha and interleukin-1 beta (P < 0.05) and increased secretory immunoglobulin A level in the ileal mucosa (P < 0.05). In addition, MLE increased the numbers of beneficial bacteria Bifidobacterium and Lactobacillus (P < 0.05) and decreased the number of potential pathogenic bacteria Escherichia coli (P < 0.05) in the colon. Correspondingly, MLE supplementation reduced the pH value of colonic digesta (P < 0.05) and altered the microbial fermentation pattern of the colon by increasing the concentrations of microbial metabolites derived from carbohydrates fermentation such as lactate, acetate, butyrate and total short-chain fatty acids (P < 0.05), and decreasing the concentrations of microbial metabolites derived from amino acid fermentation such as p-cresol, skatole, spermine, histamine and tryptamine (P < 0.05). CONCLUSION MLE supplementation improved intestinal barrier function and displayed beneficial effects on colon microbes and microbial metabolism in weaned piglets. (c) 2022 Society of Chemical Industry.
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