The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice
文献类型： 外文期刊
作者： Ye, Xuewei 1 ; Pi, Xionge 3 ; Zheng, Wenxin 2 ; Cen, Yingxin 2 ; Ni, Jiahui 2 ; Xu, Langyu 2 ; Wu, Kefei 2 ; Liu, Wei 3 ; Li, Lanjuan 1 ;
作者机构： 1.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Dis, State Key Lab Diag & Treatment Infect Dis, Hangzhou, Peoples R China
2.Zhejiang Shuren Univ, Shulan Int Med Coll, Dept Basic Med Sci, Key Lab Pollut Exposure & Hlth Intervent Zhejiang, Hangzhou, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou, Peoples R China
关键词： Polygonatum odoratum; DSS-induced colitis mice; gas production; SCFAs; microbiota
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）
ISSN： 2296-861X
年卷期： 2022 年 9 卷
页码：
收录情况： SCI
摘要： The potential impacts of methanol extract from Polygonatum odoratum on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated that YZM increased colon length and ameliorated colonic histopathology in DSS-induced colitis mice. Moreover, YZM administration reversed intestinal microbiota compositions leading to the inhibition of H2S-related bacteria (e.g., Desulfovibrionaceae) and the lower level of H2S and higher contents of SCFA-related bacteria (e.g., Muribaculaceae). Taken together, the effects of methanol extract from Polygonatum odoratum are studied to provide new enlightenment and clues for its application as a functional food and clinical drug. Our study first revealed the relationship between intestinal gas production and key bacteria in ulcerative colitis.
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