Dietary dibutyryl cAMP supplementation regulates the fat deposition in adipose tissues of finishing pigs via cAMP/PKA pathway
文献类型： 外文期刊
作者： Zhu, Cui 1 ; Wang, Li 1 ; Nie, Xiaoyan 2 ; Yang, Xuefen 1 ; Gao, Kaiguo 1 ; Jiang, Zongyong 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Maoming Branch, State Key Lab Livestock & Poultry Breeding, Minist Agr Key Lab Anim Nutr & Feed Sci South Chi, Guangzhou, Peoples R China
2.Foshan Univ, Sch Life Sci & Engn, Foshan, Peoples R China
关键词： Dibutyryl-cAMP; preadipocytes; proliferation; differentiation; adipogenesis; fat deposition
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： This study investigated potential mechanism of dibutyryl-cAMP (db-cAMP) on porcine fat deposition. (1) Exp.1, 72 finishing pigs were allotted to 3 treatments (0, 10 or 20 mg/kg dbcAMP) with 6 replicates. dbcAMP increased the hormone sensitive lipase (HSL) activity and expression of beta-adrenergic receptor (beta-AR) and growth hormone receptor (GHR), but decreased expression of peroxisome proliferator-activated receptor gamma 2 (PPAR-gamma 2) and adipocyte fatty acid binding protein (A-FABP) in back fat. dbcAMP upregulated expression of beta-AR, GHR, PPAR-gamma 2 and A-FABP, but decreased insulin receptor (INSR) expression in abdominal fat. Dietary dbcAMP increased HSL activity and expression of G protein-coupled receptor (GPCR), cAMP-response element-binding protein (CREB) and insulin-like growth factor-1 (IGF-1), but decreased fatty acid synthase (FAS) and lipoprotein lipase (LPL) activities, and expression of INSR, cAMP-response element-binding protein (C/EBP-alpha) and A-FABP in perirenal fat. (2) Exp. 2, dbcAMP suppressed the proliferation and differentiation of porcine preadipocytes in a time- and dose-dependent manner, which might be associated with increased activities of cAMP and protein kinase A (PKA), and expression of GPCR, beta-AR, GHR and CREB via inhibiting C/EBP-alpha and PPAR-gamma 2 expression. Collectively, dbcAMP treatment may reduce fat deposition by regulating gene expression related to adipocyte differentiation and fat metabolism partially via cAMP-PKA pathway.
- 相关文献
作者其他论文 更多>>
-
Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response
作者：Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong;Wu, Jing;Lu, Qi;Hou, Jing;Qiu, Yueqin;Tian, Min;Wang, Li;Gao, Kaiguo;Yang, Xuefen;Jiang, Zongyong
关键词：Piglets; PRRSV; baicalein; EGFR; MD simulation
-
Effect of Gardeniae Fructus Powder on Growth Performance, Antioxidant Capacity, Intestinal Barrier Function, and Colonic Microbiota of Weaned Piglets
作者：Liu, Shilong;Ma, Ming;Guo, Shining;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen;Liu, Shilong;Tian, Min;Qiu, Yueqin;Tang, Jiaxi;Hou, Jing;Lu, Qi;Tian, Chaoyang;Ye, Guohao;Wang, Li;Gao, Kaiguo;Jiang, Zongyong;Yang, Xuefen
关键词：piglet; Gardeniae Fructus; antioxidant capacity; intestinal barrier function; colonic microbiota
-
The Antinutritional Factors and Technological Processing of Sorghum and Its Application in Pig Production
作者：Zhang, Jianjian;Li, Ping;Yang, Xuefen;Wang, Li
关键词：sorghum; antinutritional factors; nutrient value; pig
-
Dietary bile acid supplementation improves the intestinal health and growth performance of piglets partially through the FXR/AQPs pathway
作者：Zhang, Beibei;Tian, Min;Yang, Yahui;Qiu, Yueqin;Wang, Li;Xiao, Hao;Zhu, Xiaoping;Yang, Xuefen;Jiang, Zongyong;Tian, Min;Qiu, Yueqin;Wang, Li;Xiao, Hao;Zhu, Xiaoping;Yang, Xuefen;Jiang, Zongyong;Tian, Min;Qiu, Yueqin;Wang, Li;Xiao, Hao;Zhu, Xiaoping;Yang, Xuefen;Jiang, Zongyong;Tian, Min;Qiu, Yueqin;Wang, Li;Xiao, Hao;Zhu, Xiaoping;Yang, Xuefen;Jiang, Zongyong;Qin, Limei
关键词：Bile acid; Piglet; Growth performance; Gut health; FXR
-
Effects of Dietary Ratio of Insoluble Fiber to Soluble Fiber on Reproductive Performance, Biochemical Parameters, and Fecal Microbial Composition of Gestating Sows
作者：Wen, Xiaolu;Wu, Qiwen;Gao, Kaiguo;Yang, Xuefen;Xiao, Hao;Jiang, Zongyong;Wang, Li;Wen, Xiaolu;Wu, Qiwen;Gao, Kaiguo;Yang, Xuefen;Xiao, Hao;Jiang, Zongyong;Wang, Li;Wen, Xiaolu;Wu, Qiwen;Gao, Kaiguo;Yang, Xuefen;Xiao, Hao;Jiang, Zongyong;Wang, Li;Wen, Xiaolu;Wu, Qiwen;Gao, Kaiguo;Yang, Xuefen;Xiao, Hao;Jiang, Zongyong;Wang, Li
关键词：sow; soluble fiber; insoluble fiber; fecal microbial; reproductive performance
-
Preliminary Research on Dietary Supplementation of Potassium Magnesium Sulphate on Transport Stress in Finishing Pigs Prior to Slaughter
作者：Cui, Bailei;Xiong, Yunxia;Wen, Xiaolu;Wu, Shengnan;Xiao, Hao;Cao, Shuting;Jiang, Zongyong;Wang, Li;Hu, Shenglan;Cui, Bailei;Huang, Yi
关键词：potassium magnesium sulphate; transport stress; finishing pigs; meat quality; stress response
-
Impact of Low-Dose Amino Acid-Chelated Trace Minerals on Performance, Antioxidant Capacity, and Fecal Excretion in Growing-Finishing Pigs
作者：Xiong, Yunxia;Li, Yaojie;Wu, Qiwen;Xiao, Huaqin;Cao, Shuting;Yang, Xuefen;Gao, Kaiguo;Jiang, Zongyong;Hu, Shenglan;Wang, Li;Zhao, Fei
关键词：amino acid-chelated trace minerals; meat quality; antioxidant capacity; fecal excretion; growing-finishing pigs
