Dietary dibutyryl cAMP supplementation regulates the fat deposition in adipose tissues of finishing pigs via cAMP/PKA pathway
文献类型： 外文期刊
作者： Zhu, Cui 1 ; Wang, Li 1 ; Nie, Xiaoyan 2 ; Yang, Xuefen 1 ; Gao, Kaiguo 1 ; Jiang, Zongyong 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Maoming Branch, State Key Lab Livestock & Poultry Breeding, Minist Agr Key Lab Anim Nutr & Feed Sci South Chi, Guangzhou, Peoples R China
2.Foshan Univ, Sch Life Sci & Engn, Foshan, Peoples R China
关键词： Dibutyryl-cAMP; preadipocytes; proliferation; differentiation; adipogenesis; fat deposition
期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.141； 五年影响因子：1.92 ）
ISSN： 1049-5398
年卷期：
页码：
收录情况： SCI
摘要： This study investigated potential mechanism of dibutyryl-cAMP (db-cAMP) on porcine fat deposition. (1) Exp.1, 72 finishing pigs were allotted to 3 treatments (0, 10 or 20 mg/kg dbcAMP) with 6 replicates. dbcAMP increased the hormone sensitive lipase (HSL) activity and expression of beta-adrenergic receptor (beta-AR) and growth hormone receptor (GHR), but decreased expression of peroxisome proliferator-activated receptor gamma 2 (PPAR-gamma 2) and adipocyte fatty acid binding protein (A-FABP) in back fat. dbcAMP upregulated expression of beta-AR, GHR, PPAR-gamma 2 and A-FABP, but decreased insulin receptor (INSR) expression in abdominal fat. Dietary dbcAMP increased HSL activity and expression of G protein-coupled receptor (GPCR), cAMP-response element-binding protein (CREB) and insulin-like growth factor-1 (IGF-1), but decreased fatty acid synthase (FAS) and lipoprotein lipase (LPL) activities, and expression of INSR, cAMP-response element-binding protein (C/EBP-alpha) and A-FABP in perirenal fat. (2) Exp. 2, dbcAMP suppressed the proliferation and differentiation of porcine preadipocytes in a time- and dose-dependent manner, which might be associated with increased activities of cAMP and protein kinase A (PKA), and expression of GPCR, beta-AR, GHR and CREB via inhibiting C/EBP-alpha and PPAR-gamma 2 expression. Collectively, dbcAMP treatment may reduce fat deposition by regulating gene expression related to adipocyte differentiation and fat metabolism partially via cAMP-PKA pathway.
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