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Research Progress of Immunomodulation on Anti-COVID-19 and the Effective Components from Traditional Chinese Medicine

文献类型： 外文期刊

作者： Hu, Ting 1 ; Li, Li 1 ; Ma, Qin 2 ;

作者机构： 1.Wuhan Inst Technol, Sch Environm Ecol & Biol Engn, Key Lab Green Chem Proc,Minist Educ, Hubei Key Lab Novel Reactor & Green Chem Technol, Wuhan 430205, Peoples R China

2.Guangdong Acad Agr Sci, Key Lab Funct Foods, Key Lab Agr Prod Proc, Minist Agr & Rural Affairs Guangdong,Sericultural, Guangzhou 510610, Peoples R China

3.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, 133 Yiheng Rd Dongguanzhuang, Guangzhou 510610, Peoples R China

关键词： Traditional Chinese Medicine; SARS-CoV-2; 3C-Like Protease; Flavonoids; Immunoactivity; Review

期刊名称：AMERICAN JOURNAL OF CHINESE MEDICINE （ 影响因子：5.7； 五年影响因子：5.0 ）

ISSN： 0192-415X

年卷期： 2023 年

页码：

收录情况： SCI

摘要： SARS-CoV-2 has posed a threat to the health of people around the world because of its strong transmission and high virulence. Currently, there is no specific medicine for the treatment of COVID-19. However, for a wide variety of medicines used to treat COVID-19, traditional Chinese medicine (TCM) plays a major role. In this paper, the effective treatment of COVID-19 using TCM was consulted first, and several Chinese medicines that were frequently used apart from their huge role in treating it were found. Then, when exploring the active ingredients of these herbs, it was discovered that most of them contained flavonoids. Therefore, the structure and function of the potential active substances of flavonoids, including flavonols, flavonoids, and flavanes, respectively, are discussed in this paper. According to the screening data, these flavonoids can bind to the key proteins of SARS-CoV-2, 3CLpro, PLpro, and RdRp, respectively, or block the interface between the viral spike protein and ACE2 receptor, which could inhibit the proliferation of coronavirus and prevent the virus from entering human cells. Besides, the effects of flavonoids on the human body systems are expounded on in this paper, including the respiratory system, digestive system, and immune system, respectively. Normally, flavonoids boost the body's immune system. However, they can suppress the immune system when over immunized. Ultimately, this study hopes to provide a reference for the clinical drug treatment of COVID-19 patients, and more TCM can be put into the market accordingly, which is expected to promote the development of TCM on the international stage.

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