您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis

文献类型： 外文期刊

作者： Chen, Jun 1 ; Fu, Jinping 2 ; Zhao, Sha 2 ; Zhang, Xiaoxi 2 ; Chao, Yuyang 2 ; Pan, Qunxing 2 ; Sun, Huawei 2 ; Zhang, Jingfeng 2 ; Li, Bin 2 ; Xue, Tao 5 ; Li, Jingui 1 ; Liu, Chuanmin 2 ;

作者机构： 1.Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China

3.Minist Agr, Key Lab Vet Biol Engn & Technol, Nanjing 210014, Peoples R China

4.Jiangsu Acad Agr Sci, Key Lab Vet Diag, Nanjing 210014, Peoples R China

5.Linyi Univ, Coll Med, Linyi 276000, Peoples R China

6.Jiangsu Univ, Sch Life Sci, Zhenjiang 212013, Peoples R China

7.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

关键词： viral infection; free radical; mitochondrion; ferroptosis

期刊名称：VETERINARY SCIENCES （ 影响因子：2.4； ）

ISSN：

年卷期： 2023 年 10 卷 7 期

页码：

收录情况： SCI

摘要： Simple Summary Ferroptosis is an iron-catalyzed, oxidative form of cell death. It is accompanied by a large amount of iron accumulation and lipid peroxidation. Increasingly, studies have demonstrated that ferroptosis is closely associated with various organ injuries and degenerative pathologies, among others. This review aims to investigate the molecular mechanism between free radicals and ferroptosis in the viral infection state. This review also discusses the possibility of using ferroptosis inducers and inhibitors to treat viral diseases, providing some theoretical basis for studying the pathogenesis and prevention of viruses. Free radicals, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), play critical roles in various physiological activities such as cell differentiation, apoptosis, and vascular tension when existing in cells at low levels. However, excessive amounts of free radicals are harmful, causing DNA damage, lipid peroxidation, protein degeneration, and abnormal cell death. Certain viral infections induce cells to produce excessive free radicals, which in multiple ways help the virus to replicate, mature, and exit. Iron is a necessary element for many intracellular enzymes, involved in both cellular activities and viral replication. Ferroptosis, a programmed cell death mode distinct from apoptosis, necrosis, and pyroptosis, is characterized by lipid peroxide accumulation and damage to the antioxidant system, affecting many cellular processes. Viral infection commonly manifests as decreased glutathione (GSH) content and down-regulated glutathione peroxidase 4 (GPX4) activity, similar to ferroptosis. Recent studies have suggested a possible relationship among free radicals, viral infections and ferroptosis. This review aims to elucidate the molecular mechanism linking free radicals and ferroptosis during viral infections and provide a new theoretical basis for studying viral pathogenesis and control.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台