Folic acid-coupled phosphorylated Fe2+ chelating peptide: The properties of Fe2+ chelating capacity and mechanisms of anti-gastrointestinal enzyme degradation
文献类型： 外文期刊
作者： Lin, Shanting 1 ; Hu, Xiao 2 ; Chen, Shengjun 2 ; Huang, Hui 2 ; Long, Xiaoshan 2 ; Li, Zhenxing 1 ;
作者机构： 1.Ocean Univ China, Coll Food Sci & Engn, State Key Lab Marine Food Proc & Safety Control, Qingdao 266003, Peoples R China
2.Chinese Acad Fishery Sci, Minist Agr & Rural Affairs, South China Sea Fisheries Res Inst, Key Lab Aquat Prod Proc, 231 West Xingang Rd, Guangzhou 510300, Guangdong, Peoples R China
3.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang 222005, Peoples R China
4.Sanya Trop Fisheries Res Inst, Sanya 572018, Hainan, Peoples R China
关键词： Fe 2 + chelating peptide; Phosphorylation; Fe 2 + chelating capacity; Folic acid-coupling; Anti-degradation
期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）
ISSN： 2212-4292
年卷期： 2024 年 62 卷
页码：
收录情况： SCI
摘要： The aims of this study were to investigate the effect of precise phosphorylation of Ser in GL-Hyp-GPSGEEGKR on its Fe2+ chelating capacity, and the effects and mechanisms of folic acid coupling to GL-Hyp-GPS(PO4)GEEGKR on its resistance against degradation by gastrointestinal enzymes. The results demonstrated that GL-Hyp-GPS(PO4)- GEEGKR exhibited significantly enhanced Fe2+ chelating capability compared to GL-Hyp-GPSGEEGKR. This was attributed to the phosphorylation of Ser introducing more Fe2+ chelating sites. Furthermore, the results of UV-Vis, FTIR, and 1 H NMR showed that folic acid has successfully coupled with GL-Hyp-GPS(PO4)GEEGKR to generate folic acid-GL-Hyp-GPS(PO4)GEEGKR. Folic acid-GL-Hyp-GPS(PO4)GEEGKR demonstrated superior resistance against degradation by gastrointestinal enzymes. This may be attributed to the coupling of folic acid altering the original zeta potential of the peptide and the steric hindrance effect of folic acid hindering the interaction between enzymes and peptide. These findings can provide valuable insights for the production of high Fe2+ chelating peptides that resist gastrointestinal enzyme degradation.
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