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Overexpression of the Arabidopsis MACPF Protein AtMACP2 Promotes Pathogen Resistance by Activating SA Signaling

文献类型： 外文期刊

作者： Zhang, Xue 1 ; Dai, Yang-Shuo 1 ; Wang, Yu-Xin 1 ; Su, Ze-Zhuo 1 ; Yu, Lu-Jun 1 ; Zhang, Zhen-Fei 2 ; Xiao, Shi 1 ; Chen, Qin-Fang 1 ;

作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, State Key Lab Biocontrol, Guangzhou 510275, Peoples R China

2.Guangdong Acad Agr Sci, Plant Protect Res Inst, Guangzhou 510640, Peoples R China

3.Univ Hong Kong, Li Ka Shing Fac Med, Pokfulam, Sch Biomed Sci, Hong Kong, Peoples R China

4.Lab Data Discovery Hlth Ltd D24H, Hong Kong Sci Pk, Hong Kong, Peoples R China

关键词： MACP2; membrane attack complex; perforin-like protein; pathogen infection; salicylic acid signaling; indole glucosinolates

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 15 期

页码：

收录情况： SCI

摘要： Immune response in plants is tightly regulated by the coordination of the cell surface and intracellular receptors. In animals, the membrane attack complex/perforin-like (MACPF) protein superfamily creates oligomeric pore structures on the cell surface during pathogen infection. However, the function and molecular mechanism of MACPF proteins in plant pathogen responses remain largely unclear. In this study, we identified an Arabidopsis MACP2 and investigated the responsiveness of this protein during both bacterial and fungal pathogens. We suggest that MACP2 induces programmed cell death, bacterial pathogen resistance, and necrotrophic fungal pathogen sensitivity by activating the biosynthesis of tryptophan-derived indole glucosinolates and the salicylic acid signaling pathway dependent on the activity of enhanced disease susceptibility 1 (EDS1). Moreover, the response of MACP2 mRNA isoforms upon pathogen attack is differentially regulated by a posttranscriptional mechanism: alternative splicing. In comparison to previously reported MACPFs in Arabidopsis, MACP2 shares a redundant but nonoverlapping role in plant immunity. Thus, our findings provide novel insights and genetic tools for the MACPF family in maintaining SA accumulation in response to pathogens in Arabidopsis.

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