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Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos

文献类型： 外文期刊

作者： Gong, Husile 1 ; Wang, Hong 1 ; Wang, YueXing 1 ; Bai, Xue 1 ; Liu, Bin 1 ; He, JinFeng 3 ; Wu, JiangHong 2 ; Qi, WangMei 3 ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot, Peoples R China

2.Inner Mongolia Acad Agr & Anim Husb Sci, Anim Husb Inst, Hohhot, Peoples R China

3.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot, Peoples R China

4.Chinese Acad Sci, Inner Mongolia Prataculture Res Ctr, Hohhot, Peoples R China

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2018 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Avian species have a unique integument covered with feathers. Skin morphogenesis is a successive and complex process. To date, most studies have focused on a single developmental point or stage. Fewer studies have focused on whole transcriptomes based on the time-course of embryo integument development. To analyze the global changes in gene expression profiles, we sequenced the transcriptome of chicken embryo skin samples from day 6 to day 21 of incubation and identified 5830 differentially expressed genes (DEGs). Hierarchical clustering showed that E6 to E14 is the critical period of feather follicle morphogenesis. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the DEGs, two kinds of Wnt signaling pathways (a canonical pathway and a non-canonical pathway) changed during feather follicle and feather morphogenesis. The gene expression level of inhibitors and ligands related to the Wnt signaling pathway varied significantly during embryonic development. The results revealed a staggered phase relationship between the canonical pathway and the non-canonical pathway from E9 to E14. These analyses shed new light on the gene regulatory mechanism and provided fundamental data related to integument morphogenesis of chickens.

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