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Expression of Vimentin in hair follicle growth cycle of inner Mongolian Cashmere goats

文献类型： 外文期刊

作者： Rile, Nai 1 ; Liu, Zhihong 1 ; Gao, Lixia; Qi, Jingkai; Zhao, Meng; Xie, Yuchun 1 ; Su, Rui 1 ; Zhang, Yanjun 1 ; W 1 ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Anim Sci, Hohhot 010018, Peoples R China

2.Key Lab Anim Genet Breeding & Reprod, Hohhot, Inner Mongolia, Peoples R China

3.Minist Agr, Key Lab Mutton Sheep Genet & Breeding, Hohhot, Peoples R China

4.Engn Res Ctr Goat Genet & Breeding, Hohhot, Inner Mongolia, Peo

关键词： Cashmere goat;Skin;Hair follicle;Growth cycle;Vimentin

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2018 年 19 卷

页码：

收录情况： SCI

摘要： Background: The growth of Inner Mongolian Cashmere goat skin hair follicle exhibits a periodic growth pattern. The hair growth cycle is distinguished as telogen, anagen, and catagen stages. The role of vimentin in the growth process of hair follicles is evident. To elucidate the mechanism underlying the vimentin activity in the growth cycle of hair follicles, transcriptome sequencing and liquid chromatography-tandem mass spectrometry were used to obtain the nucleic acid and amino acid sequences of VIIM gene and vimentin. The amino acid and nucleic acid sequences were analyzed by comparison. Real-time quantitative PCR, Western blot, and immunohistochemistry analyzed the expression level and sites of vimentin in the three growth stages of the Inner Mongolia Cashmere goat skin samples. Results: VIM gene cDNA, obtained by transcriptome sequencing, was aligned against that of the Capra hircus VIM gene. The amino acid sequence of vimentin revealed a high similarity rate across other species. The expressions of both VIM gene and vimentin were highest during the growth period and lowest in the rest period. Furthermore, vimentin was primarily expressed in the outer root sheath of the hair follicle as assessed by staining. Conclusions: The sequences of the gene and protein are similar to that of other species and identical to Capra hircus. However, the expression of VIM and vimentin was proportional to that of the growth of hair follicles. And vimentin expressed only in the outer root sheath of hair follicles. Thus, vimentin was speculated to participate in the regulation of the hair follicle growth cycle by affecting the outer root sheath.

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