Antibiotic resistance at environmental multi-media interfaces through integrated genotype and phenotype analysis
文献类型： 外文期刊
作者： Fu, Chen-Xi 1 ; Chen, Chen 4 ; Xiang, Qian 5 ; Wang, Yi-Fei 5 ; Wang, Lu 5 ; Qi, Feng-Yuan 1 ; Zhu, Dong 5 ; Li, Hong-Zhe 9 ; Cui, Li 9 ; Hong, Wei-Li 4 ; Rillig, Matthias C. 7 ; Zhu, Yong-Guan 1 ; Qiao, Min 1 ;
作者机构： 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Zhejiang Acad Agr Sci, Inst Environm Resource Soil & Fertilizer, Hangzhou 310021, Peoples R China
4.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China
5.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Ningbo Urban Environm Observat & Res Stn, Xiamen 361021, Peoples R China
6.CAS Haixi Ind Technol Innovat Ctr Beilun, Zhejiang Key Lab Urban Environm Proc & Pollut Cont, Ningbo 315830, Peoples R China
7.Free Univ Berlin, Inst Biol, Berlin, Germany
8.Berlin Brandenburg Inst Adv Biodivers Res BBIB, Berlin, Germany
9.Chinese Acad Sci, Key Lab Urban Environm & Hlth, Inst Urban Environm, Xiamen 361021, Peoples R China
关键词： Multi-media interface; Phenotypic resistance; Stimulated Raman scattering; Antibiotic resistance genes; Resistant bacteria
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：11.3； 五年影响因子：12.4 ）
ISSN： 0304-3894
年卷期： 2024 年 480 卷
页码：
收录情况： SCI
摘要： Antibiotic resistance is currently an unfolding global crisis threatening human health worldwide. While antibiotic resistance genes (ARGs) are known to be pervasive in environmental media, the occurrence of antibiotic resistance at interfaces between two or more adjacent media is largely unknown. Here, we designed a microcosm study to simulate plastic pollution in paddy soil and used a novel method, stimulated Raman scattering coupled with deuterium oxide (D2O) 2 O) labelling, to compare the antibiotic resistance in a single medium with that at the interface of multiple environmental media (plastic, soil, water). Results revealed that the involvement of more types of environmental media at interfaces led to a higher proportion of active resistant bacteria. Genotypic analysis showed that ARGs (especially high-risk ARGs) and mobile genetic elements (MGEs) were all highly enriched at the interfaces. This enrichment was further enhanced by the co-stress of heavy metal (arsenic) and antibiotic (ciprofloxacin). Our study is the first to apply stimulated Raman scattering to elucidate antibiotic resistance at environmental interfaces and reveals novel pathway of antibiotic resistance dissemination in the environment and overlooked risks to human health.
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