文献类型： 外文期刊

作者： Su, Chun-xia ¹ ; Duan, Xiang-guo ² ; Liang, Li-jun ⁵ ; Feng-Wang ¹ ; Zheng, Jie ¹ ; Fu, Xue-Yan ⁶ ; Yan, Ya-mei ⁷ ; Ling- ¹ ;

作者机构： 1.Ningxia Med Univ, Sch Basic Med Sci, Ningxia 750004, Peoples R China

2.Ningxia Med Univ, Lab Examinat Coll, Ningxia 750004, Peoples R China

3.Ningxia Med Univ, Lab Examinat Res Inst, Ningxia 750004, Peoples R China

4.Ningxia Med Univ, Gen Hosp, Stem Cell Res Inst, Ningxia 750004, Peoples R China

5.Ningxia Med Univ, Gen Hosp, Ningxia 750004, Peoples R China

6.Ningxia Med Univ, Coll Pharm, Ningxia 750004, Peoples R China

7.Ningxia Acad Agr & Forestry Sci, Ningxia 640100, Peoples R China

关键词： Lycium barbarum polysaccharides;Follicular helper T cells;Adjuvant

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2014 年 158 卷 1-2 期

页码：

收录情况： SCI

摘要： Lycium barbarum polysaccharides (LBP) have been shown to play a variety of immunemodulatory functions which include activation of T and B cells. Follicular helper T (Tfh) cells are now recognized as a subset of helper T cells which regulate the multiple stages of B cell maturation and function. In our current study, we found that LBP were able to activate CXCR5+PD-1+ Tfh cells and induce IL-21 secretion. At the same time LBP also promoted the formation of germinal centers (GC) and production of GL-7+B220+GC B cells. LBP as an adjuvant could increase generation of rAd5VP1-induced Tfh cells. Our results indicate that LBP might enhance T cell-dependent Ab responses by acting as an adjuvant for the generation of Tfh cells. Future vaccine designs might therefore be targeted to induce strong antigen-specific Tfh responses in order to boost its protective effects. (C) 2013 Elsevier B.V. All rights reserved.