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miRNAome, mRNAome and degradome analysis of Tibetan minipigs anterior pituitary

文献类型： 外文期刊

作者： Ye, Rui-Song 1 ; Li, Meng 1 ; Chen, Ting 1 ; Wei, Xiao-Chen 1 ; Qi, Qi-En 2 ; Cheng, Xiao; Li, Chao-Yun; Jiang, Qin 1 ;

作者机构： 1.South China Agr Univ, Chinese Natl Engn Res Ctr Breeding Swine Ind, Coll Anim Sci,SCAU Alltech Res Joint Alliance, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

2.South China Agr Univ, Chinese Natl Engn Res Ctr Breeding Swine Ind, Coll Anim Sci,SCAU Alltech Res Joint Alliance, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou

关键词： Pig;miRNA;Anterior pituitary;Targets

期刊名称：GENERAL AND COMPARATIVE ENDOCRINOLOGY （ 影响因子：2.822； 五年影响因子：2.772 ）

ISSN： 0016-6480

年卷期： 2018 年 259 卷

页码：

收录情况： SCI

摘要： Tibetan minipig is an important animal model for human diseases. The anterior pituitary is the master gland responsible for growth, reproduction, and metabolism and is regulated by thousands of miRNAs/mRNAs molecules. However, little is known about miRNAs and their relationships with mRNAs in Tibetan minipig anterior pituitary. Using microarray and mRNA-Sequencing, we identified 203 miRNAs and 12,040 mRNA transcripts from the anterior pituitary of Tibetan minipigs. These miRNAs were corresponding to 194 hairpin precursors, 25 miRNA clusters and 24 miRNA families. In addition, 64 intragenic miRNAs were annotated. Using three bioinformatic algorithms (TargetScan, miRanda and RNAhybrid), 359,184 possible miRNA-mRNA interactions were predicted, and an integrated network of miRNAs and pituitary-specific mRNA transcripts was established. To validate the predicted results, the degradome sequencing was employed to confirm miRNA-mRNA interactions, totally, 30 miRNA-mRNA pairs were identified. The present study provided a general overview of miRNA and mRNA annotation in Tibetan minipig anterior pituitary and established a miRNA-mRNA interactions database at the whole genome scale, which helps shed light on the molecular mechanisms in the anterior pituitary of pigs even other mammals. (C) 2017 Elsevier Inc. All rights reserved.

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