Genome Wide Association Analysis Reveals New Production Trait Genes in a Male Duroc Population
文献类型： 外文期刊
作者： Wang, Kejun 1 ; Liu, Dewu 2 ; Hernandez-Sanchez, Jules 3 ; Chen, Jie 1 ; Liu, Chengkun 1 ; Wu, Zhenfang 2 ; Fang, Meiy 1 ;
作者机构： 1.China Agr Univ, Coll Anim Sci & Technol, MOA Lab Anim Genet & Breeding, Dept Anim Genet & Breeding,Natl Engn Lab Anim Bre, Beijing 100193, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China
3.Queensland Univ Technol, Inst Hlth & Biomed Innovat, Res Methods Grp, Kelvin Grove, Qld 4059, Australia
4.China Agr Univ, State Key L
期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）
ISSN： 1932-6203
年卷期： 2015 年 10 卷 9 期
页码：
收录情况： SCI
摘要： In this study, 796 male Duroc pigs were used to identify genomic regions controlling growth traits. Three production traits were studied: food conversion ratio, days to 100 KG, and average daily gain, using a panel of 39,436 single nucleotide polymorphisms. In total, we detected 11 genome-wide and 162 chromosome-wide single nucleotide polymorphism trait associations. The Gene ontology analysis identified 14 candidate genes close to significant single nucleotide polymorphisms, with growth-related functions: six for days to 100 KG (WT1, FBXO3, DOCK7, PPP3CA, AGPAT9, and NKX6-1), seven for food conversion ratio (MAP2, TBX15, IVL, ARL15, CPS1, VWC2L, and VAV3), and one for average daily gain (COL27A1). Gene ontology analysis indicated that most of the candidate genes are involved in muscle, fat, bone or nervous system development, nutrient absorption, and metabolism, which are all either directly or indirectly related to growth traits in pigs. Additionally, we found four haplotype blocks composed of suggestive single nucleotide polymorphisms located in the growth trait-related quantitative trait loci and further narrowed down the ranges, the largest of which decreased by similar to 60 Mb. Hence, our results could be used to improve pig production traits by increasing the frequency of favorable alleles via artificial selection.
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