您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Variation in sequence and expression of the avian FTO, and association with glucose metabolism, body weight, fatness and body composition in chickens

文献类型： 外文期刊

作者： Jia, X. 1 ; Nie, Q. 1 ; Lamont, S. J. 2 ; Zhang, X. 1 ;

作者机构： 1.S China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China

2.Iowa State Univ, Dept Anim Sci, Ames, IA USA

3.Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Guangdong, Peoples R China

关键词： FTO;avian;chicken;fatness;association analysis

期刊名称：INTERNATIONAL JOURNAL OF OBESITY （ 影响因子：5.095； 五年影响因子：5.804 ）

ISSN： 0307-0565

年卷期： 2012 年 36 卷 8 期

页码：

收录情况： SCI

摘要： OBJECTIVE: The fat mass and obesity-associated gene (FTO), a crucial gene that affects human obesity and metabolism, has been widely studied in mammals but remains poorly characterized in birds. We aimed to identify variant FTO transcripts in domestic avian species, and to characterize the expression and biological functions of FTO in chickens. METHODS: Variant FTO transcripts and their expression in birds were investigated using RACE and real-time quantitative reverse transcriptase-PCR technology. The effects of FTO on glucose metabolism, growth and body composition were determined by fasting and various diet treatments, as well as association analysis in a F-2 resource population. The function of cFTO1 was further studied by overexpression in chick embryo fibroblast (CEF) cells. RESULTS: Variant FTO transcripts were identified in chicken (cFTO1 to cFTO4), duck (dFTO1, dFTO2 and dFTO4) and goose (gFTO1, gFTO2 and gFTO5). In the chicken, the complete transcript (cFTO1) was predominantly expressed in the leg muscle, pituitary, hypothalamus and cerebellum. Fasting increased both cFTO1 and PGC1 alpha gene expression in the cerebrum, liver, breast muscle and subcutaneous fat, but decreased expression in the pituitary and anterior hypothalamus. In all tested tissues in chickens, a high-glucose diet markedly increased cFTO1 and PGC1 alpha expression. Feeding a high-fat diet increased both cFTO1 and PGC1 alpha expression, except in the pituitary. Overexpression of cFTO1 in CEF cells significantly increased the expression of PGC1 alpha (2.5-fold), STAT3 (2.2-fold) and HL (1.5-fold), a cluster of genes related to energy metabolism. A total of 65 single nucleotide polymorphisms (SNPs) were identified in chicken FTO, and 18 tested SNPs were significantly associated with traits of body weight, body composition and fatness. CONCLUSIONS: These data collectively indicate that FTO is related to glucose metabolism, body weight, fatness and body composition in birds, thus expanding knowledge of FTO function to non-mammalian species.

  • 相关文献

[1]Expression of variant transcripts of the potassium channel tetramerization domain-containing 15 (KCTD15) gene and their association with fatness traits in chickens. Liang, S. S.,Ouyang, H. J.,Liu, J.,Chen, B.,Nie, Q. H.,Zhang, X. Q.,Liang, S. S.,Ouyang, H. J.,Liu, J.,Chen, B.,Nie, Q. H.,Zhang, X. Q.,Liang, S. S.,Ouyang, H. J.,Liu, J.,Chen, B.,Nie, Q. H.,Zhang, X. Q..

[2]NHE1 gene associated with avian leukosis virus subgroup J infection in chicken. Chen, Biao,Pan, Weiling,Zhang, Liangyu,Liu, Jing,Ouyang, Hongjia,Nie, Qinghua,Zhang, Xiquan,Chen, Biao,Pan, Weiling,Zhang, Liangyu,Liu, Jing,Ouyang, Hongjia,Nie, Qinghua,Zhang, Xiquan,Chen, Biao,Pan, Weiling,Zhang, Liangyu,Liu, Jing,Ouyang, Hongjia,Nie, Qinghua,Zhang, Xiquan.

[3]Polymorphisms associated with egg number at 300 days of age in chickens. Xu, H. P.,Zeng, H.,Zhang, D. X.,Jia, X. L.,Nie, Q. H.,Zhang, X. Q.,Luo, C. L.,Fang, M. X.. 2011

[4]Effects of abhydrolase domain containing 5 gene (ABHD5) expression and variations on chicken fat metabolism. Ouyang, Hongjia,Liu, Qing,Xu, Jiguo,Zeng, Fang,Pang, Xiaolin,Jebessa, Endashaw,Liang, Shaodong,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,Liu, Qing,Xu, Jiguo,Zeng, Fang,Pang, Xiaolin,Jebessa, Endashaw,Liang, Shaodong,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,Liu, Qing,Xu, Jiguo,Zeng, Fang,Pang, Xiaolin,Jebessa, Endashaw,Liang, Shaodong,Nie, Qinghua,Zhang, Xiquan.

[5]Associations of IGF2 and DRD2 polymorphisms with laying traits in Muscovy duck. Nie, Qinghua. 2017

[6]Identification and characterization of RFRP gene in pigs and its association with reproductive traits. Fang, M. X.,Huang, Y. S.,Ye, J.,Zhang, W.,Nie, Q. H.,Huang, Y. S.,Ye, J.,Zhang, W.,Nie, Q. H.,Li, Y.. 2014

[7]Deep Sequencing Analysis of miRNA Expression in Breast Muscle of Fast-Growing and Slow-Growing Broilers. Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan. 2015

[8]A premature stop codon within the tvb receptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E. Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Li, Aijun,Shu, Dingming,Zhang, Huanmin,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei. 2017

[9]Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Wang, Q.,Li, H.,Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Li, H.,Wang, Q.. 2013

[10]An association between genetic variation in the roundabout, axon guidance receptor, homolog 2 gene and immunity traits in chickens. Shu, D. M.. 2014

[11]Differentially expressed genes in the liver of lean and fat chickens. He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Li, H.,Wang, Q. G.. 2014

[12]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[13]Biological Characteristics of Chinese Precocious Strain of Eimeria acervulina and Its Immune Efficacy Against Different Field Strains. Wu, Lin-Lin,Lin, Rui-Qing,Duan, Wen-Fang,Zou, Shang-Shu,Yuan, Zi-Guo,Weng, Ya-Biao,Sun, Ming-Fei,Liu, Li-Dan. 2014

[14]Genome-wide association study of antibody response to Newcastle disease virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Li, Chunyu,Yang, Chunfen,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Li, Chunyu,Yang, Chunfen,Hu, Xiaoxiang,Shu, Dingming. 2013

[15]Identification of genome-wide SNP-SNP interactions associated with important traits in chicken. Zhang, Hui,Yu, Jia-Qiang,Yang, Li-Li,Zhang, Xin-Yang,Na, Wei,Li, Hui,Zhang, Hui,Yu, Jia-Qiang,Yang, Li-Li,Zhang, Xin-Yang,Na, Wei,Li, Hui,Zhang, Hui,Yu, Jia-Qiang,Yang, Li-Li,Zhang, Xin-Yang,Na, Wei,Li, Hui,Kramer, Luke M.,Reecy, James M.. 2017

[16]Identification and Analysis of a Functional SNP 1196C > A in 3 ' UTR of Chicken IGFBP2 Gene. Yu Ying-Ying,Qiao Shu-Pei,Sun Ying-Ning,Song He,Zhang Xiao-Fei,Yan Xiao-Hong,Li Hui,Wang Ning,Yu Ying-Ying,Qiao Shu-Pei,Sun Ying-Ning,Song He,Zhang Xiao-Fei,Yan Xiao-Hong,Li Hui,Wang Ning,Yu Ying-Ying,Qiao Shu-Pei,Sun Ying-Ning,Song He,Zhang Xiao-Fei,Yan Xiao-Hong,Li Hui,Wang Ning,Sun Ying-Ning. 2014

[17]Let-7b Regulates Myoblast Proliferation by Inhibiting IGF2BP3 Expression in Dwarf and Normal Chicken. Lin, Shumao,Luo, Wen,Bekele, Endashaw J.,Nie, Qinghua,Zhang, Xiquan,Lin, Shumao,Luo, Wen,Bekele, Endashaw J.,Nie, Qinghua,Zhang, Xiquan,Lin, Shumao,Luo, Wen,Bekele, Endashaw J.,Nie, Qinghua,Zhang, Xiquan,Lin, Shumao,Ye, Yaqiong,Ye, Yaqiong,Li, Yugu. 2017

[18]Copy Number Variation in SOX6 Contributes to Chicken Muscle Development. Lin, Shudai,Lin, Xiran,Zhang, Zihao,Jiang, Mingya,Nie, Qinghua,Zhang, Xiquan,Rao, Yousheng. 2018

[19]Detection of genome-wide copy number variations in two chicken lines divergently selected for abdominal fat content. Zhang, Hui,Du, Zhi-Qiang,Dong, Jia-Qiang,Wang, Hai-Xia,Shi, Hong-Yan,Wang, Ning,Wang, Shou-Zhi,Li, Hui,Zhang, Hui,Du, Zhi-Qiang,Dong, Jia-Qiang,Wang, Hai-Xia,Shi, Hong-Yan,Wang, Ning,Wang, Shou-Zhi,Li, Hui,Zhang, Hui,Du, Zhi-Qiang,Dong, Jia-Qiang,Wang, Hai-Xia,Shi, Hong-Yan,Wang, Ning,Wang, Shou-Zhi,Li, Hui. 2014

[20]Construction of multiple linear regression models using blood biomarkers for selecting against abdominal fat traits in broilers. Dong, J. Q.,Zhang, X. Y.,Wang, S. Z.,Zhang, K.,Ma, G. W.,Wu, M. Q.,Li, H.,Zhang, H.,Dong, J. Q.,Zhang, X. Y.,Wang, S. Z.,Zhang, K.,Ma, G. W.,Wu, M. Q.,Li, H.,Zhang, H.,Dong, J. Q.,Zhang, X. Y.,Wang, S. Z.,Zhang, K.,Ma, G. W.,Wu, M. Q.,Li, H.,Zhang, H.,Dong, J. Q.,Jiang, X. F.. 2018

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台